Primary and secondary prevention of atrial fibrillation with statins and polyunsaturated fatty acids: review of evidence and clinical relevance

Naunyn-Schmiedeberg's Archives of Pharmacology
Irene SavelievaJohn Camm

Abstract

Atrial fibrillation (AF) is an increasingly common arrhythmia that now stands at epidemic proportion, with more than 2.3 million people affected in the USA and over 4.5 million people affected in Western Europe. AF is an expression of underlying heart disease and is increasingly associated with hypertension, congestive heart failure, and ischemic heart disease. It is also a progressive disease secondary to continuous structural remodeling of the atria, which relates to AF itself, to changes associated with aging and to progression of the underlying heart disease. Traditionally, AF has been addressed only after it has already presented with pharmacological and nonpharmacological therapies designed for rhythm or rate control (secondary prevention). Although secondary prevention is the most feasible approach at present, the concept of primary prevention of AF with therapies aimed at preventing the development of substrate and correcting the risk factors for AF has emerged as a strategy, which is likely to produce a larger effect in the general population. Recent experiments provided new insights into AF pathophysiology, which generated background for new mechanism-based therapies. Agents targeting inflammation, oxidative injury, a...Continue Reading

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Related Concepts

Metabolic Process, Cellular
Omega-3 Fatty Acids
Extracellular Matrix
Anti-Arrhythmia Agents
Regular Atrial Cardiac Myocyte
Antiarrhythmic [EPC]
Myocardial Ischemia
Atrial Fibrillation
Aldosterone Antagonists [MoA]
Angiotensins

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