PMID: 6169000Jun 25, 1981Paper

Primary and secondary structures of chicken, rat and man nuclear U4 RNAs. Homologies with U1 and U5 RNAs

Nucleic Acids Research
A KrolM Jacob

Abstract

U4 RNA from chicken, rat and man was examined for nucleotide sequence and secondary structure. Three molecular species, U4A, U4B and U4C were detected in the three animal species. U4A is 146 nucleotide long and U4B RNA only lacks the 3' terminal G. four nucleotides are missing at the 3'-end of U4C RNA which, in addition, differs from U4A and U4B RNAs at two internal positions. Thus, U4C RNA is encoded by another gene as U4A and U4B RNAs. Only one nucleotide substitution occurred between chicken and man showing that U4A, U4B and U4C RNAs have been extremely conserved throughout evolution. The three molecular species are capped, they contain three psi, a 2'-P methyl A and a m6A. An additional post-transcriptional modification close to the cap structure is observed in man. On the basis on an experimental study, two models of secondary structure may be proposed for U4 RNA. The 3'domain is the same in both models and is homologous to that of U1 and U5 RNAs. It consists of a single-stranded region, containing the sequence Py-(A)2-(U)n-Gp flanked by two stable hairpins probably involved in tertiary interactions. The 5' domain is less stable than the 3' domain and its structure is different in the two models. However, a long single-str...Continue Reading

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Citations

Apr 1, 1985·Molecular Biology Reports·V V GrechkoS K Vassilenko
May 22, 1981·Molecular Biology Reports·H GallinaroC Branlant
Nov 26, 2008·Journal of Molecular Evolution·Manuela MarzPeter F Stadler
Jan 1, 1986·Gene·C BarkU Pettersson
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E D WiebenT Pederson
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·E D WiebenT Pederson
Jul 1, 1983·The Journal of Cell Biology·D J ForbesM W Kirschner
Sep 1, 1984·The Journal of Cell Biology·S J MadoreT Pederson
Nov 25, 1983·Nucleic Acids Research·E LazarM Jacob
Apr 11, 1984·Nucleic Acids Research·C Hashimoto, J A Steitz
Aug 25, 1989·Nucleic Acids Research·K J McNamara, W E Stumph
Nov 25, 1989·Nucleic Acids Research·E Myslinski, C Branlant
Oct 18, 2002·Nucleic Acids Research·Luis R ComolliWilliam H Gmeiner
Feb 22, 2012·Journal of Nucleic Acids·Tae Suk Ro-Choi, Yong Chun Choi
Nov 30, 2011·Epigenomics·Jeffrey E Squires, Thomas Preiss
Dec 18, 2015·Nucleic Acids Research·Yoshio YamauchiMasato Taoka
Jul 31, 1985·Biochemical and Biophysical Research Communications·J A SabaR Reddy
Dec 25, 1984·Journal of Molecular Biology·E MyslinskiT Pederson
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Dec 1, 1983·Cell·D TollerveyC Guthrie
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Jun 2, 2015·Biotechnology Advances·Amit Kumar ChaudharyEun Yeol Lee
May 19, 2018·Nature Reviews. Drug Discovery·P Ann Boriack-SjodinRobert A Copeland

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