Primary antibody responses to thymus-independent antigens in the lungs and hilar lymph nodes of mice.

Infection and Immunity
S N GoudB Subbarao

Abstract

B lymphocytes from the pulmonary lymphoid tissues were stimulated with a variety of thymus-independent (TI) antigens by intratracheal (i.t.) immunization. Immune responses in the lungs and hilar lymph nodes (HLN), which are part of the localized lymphoid tissue, as well as in the spleen, the systemic lymphoid organ, were studied. Thus, primary i.t. immunization of mice with the TI-1 antigen trinitrophenyl-lipopolysaccharide (TNP-LPS) elicited both antigen-specific and polyclonal plaque-forming cell responses from HLN, lung, and splenic B lymphocytes. These responses appeared as early as 3 days after immunization and declined by day 7. Similar immunization with another TI-1 antigen, TNP-Brucella abortus, resulted in anti-TNP responses in both pulmonary and systemic lymphoid tissues, although the kinetics of the antibody response were different than those to TNP-LPS. Interestingly an i.t. immunization with a TI-2 antigen, TNP-Ficoll, failed to induce an anti-TNP PFC response from HLN and lung B cells, although there was good antibody formation from splenic B cells. Antibody response to TNP-Ficoll was restored in pulmonary tissues when mice were immunized with TNP-Ficoll mixed with unconjugated B. abortus. In conclusion, our resul...Continue Reading

References

Jan 1, 1979·Advances in Immunology·D C Morrison, J L Ryan
Aug 1, 1976·European Journal of Immunology·E GronowiczF Melchers
May 20, 1976·Nature·G Biberfeld, E Gronowicz
Jun 1, 1986·European Journal of Immunology·P PereiraA Coutinho
Jun 1, 1988·The American Review of Respiratory Disease·G FolkertsF P Nijkamp
Apr 1, 1986·Journal of Leukocyte Biology·J B GalvinB A Muggenburg
Jan 1, 1974·International Archives of Allergy and Applied Immunology·W R ThomasD Keast
Nov 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·M B Rittenberg, K L Pratt
Sep 1, 1983·Reviews of Infectious Diseases·E J Young
Jan 1, 1981·Infection and Immunity·E MorenoL A Boettcher
Apr 15, 1982·The New England Journal of Medicine·J E Rinaldo, R M Rogers
Nov 1, 1980·The American Review of Respiratory Disease·D E BiceR K Wolff
Apr 26, 1963·Science·N K Jerne, A A Nordin
Aug 1, 1982·Immunology Today·D E Mosier, B Subbarao
Nov 1, 1985·Immunology Today·C BergmannK Petzoldt

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Citations

Jun 1, 1994·The Anatomical Record·M N Kolopp-SardaG C Faure
Aug 1, 1996·European Journal of Immunology·R O EhrhardtW Strober
Mar 30, 2001·American Journal of Veterinary Research·M G MenseD L Hoover
Jul 17, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Li Yin DrakeHirohito Kita
Sep 27, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christina A DalyKaren M Haas

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