Primary antimicrobial resistance among Mycobacterium tuberculosis isolates from HIV seropositive and HIV seronegative patients in Dar es Salaam Tanzania.

BMC Research Notes
Willy UrassaWafaie Fawzi

Abstract

The United Republic of Tanzania is one of the 22 high M. tuberculosis burden countries. Data collected between 2002 and 2007 indicate that the global prevalence of drug-resistant M. tuberculosis including MDR vary greatly. The varied drug-resistance patterns make continuous surveillance of drug resistance an essential component of tuberculosis control program. M. tuberculosis isolates were obtained from consenting adult tuberculosis patients involved in a placebo-controlled study to evaluate the efficacy of multivitamin supplements on response to anti-Tb treatment in Dar es Salaam, Tanzania. Antimicrobial susceptibility testing was done on four antimicrobial agents namely streptomycin, isoniazid, ethambutol and rifampicin. HIV testing and CD4+ T lymphocytes enumeration were also done. A total of 280 M. tuberculosis isolates from 191 (68%) males and 89 (32%) female patients with no previous history of anti-tuberculosis treatment exceeding 4 weeks in the previous 12 months were tested. Among these, 133 (47%) patients were HIV seropositive. Fourteen (5.0%) isolates were resistant to any of the anti-tuberculosis drugs. The prevalence of primary resistance was 5.0%, 0.7%, 0.4% and 0% for isoniazid, streptomycin, rifampicin and etham...Continue Reading

References

Nov 5, 1999·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·W UrassaG Biberfeld
May 22, 2003·Tuberculosis·Marcos A Espinal
Feb 12, 2005·Emerging Infectious Diseases·Judith R GlynnPaul E M Fine
Mar 15, 2005·Scandinavian Journal of Infectious Diseases·Khalequ ZamanRobert Black
Jun 21, 2005·Emerging Infectious Diseases·Helmi MardassiKoussay Dellagi
Jul 21, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mohamed Abdel Aziz, Abigail Wright
Mar 22, 2006·AIDS·Saidi M EgwagaMartien W Borgdorff
Mar 30, 2006·Epidemiology and Infection·K ZamanR E Black
Jan 4, 2008·The Journal of Infectious Diseases·Samira Mubareka, Peter Palese
Dec 9, 2009·International Journal of Psychiatry in Medicine·Heidemarie Kremer, Gail Ironson
Aug 7, 2010·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Chia-Chuan YuChang-Hua Chen
Jan 13, 2012·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·A DramowskiH S Schaaf

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Citations

Jan 1, 2009·BMC Public Health·Timothy M ChondeSaidi M Egwaga
Sep 4, 2013·Journal of Infection and Public Health·Jitendra Prasad MathuriaShampa Anupurba
Nov 13, 2013·Tuberculosis·Benson R KidenyaDaniel W Fitzgerald
Jan 6, 2018·Journal of Global Infectious Diseases·Pallavi SinhaShampa Anupurba
Dec 23, 2011·The Journal of Nutrition·Sheila IsanakaWafaie W Fawzi

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Methods Mentioned

BETA
ELISAs
flow cytometry

Software Mentioned

Statistical Package for Social Scientists ( SPSS

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