Primary atypical carcinoid tumor of the mediastinum: a very rare finding

Journal of Thoracic Disease
Luigi VenturaLuca Ampollini

Abstract

Primary neuroendocrine tumors (NETs) of the mediastinum are very rare. Prognosis is usually poor despite treatment options. We present the case of a primary atypical carcinoid tumor of the mediastinum successfully treated by multimodal approach. A 50-year-old man presented for asthenia, dyspnea, and substernal sense of weight for two weeks. A chest-CT scan revealed a tumor mass of 107×55×95 mm3 localized in the anterosuperior mediastinum compressing both brachiocephalic veins, the superior vena cava, the pericardium, and lungs. A FDG-PET demonstrated high FDG uptake only in the mediastinal mass; no metastases were seen. CT-guided needle biopsy revealed a NET; cells were immunoreactive for synaptophysin; Ki67 was 20%. After neoadjuvant chemotherapy, the chest CT-scan showed a significant reduction of the tumor. A surgical excision was proposed. The tumor was radically removed along with a partial resection of the vena cava and reconstruction with a bovine pericardium patch. The patient underwent 25 sessions of adjuvant radiotherapy. Microscopically the tumor showed clusters of medium-sized cells, eosinophilic cytoplasm with nuclear pleomorphism and small nucleoli, arranged in trabeculae, nests and lobules. No thymic tissue was f...Continue Reading

Citations

Mar 20, 2020·Molecular and Clinical Oncology·Wei-Xia XuanXiao-Ju Zhang
Dec 14, 2019·The Korean Journal of Thoracic and Cardiovascular Surgery·Jiyun LeeKyung Soo Kim
Apr 3, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Huipan LiuYue Chen
Feb 26, 2021·Curēus·Konstantinos KosmasDimitra Riga

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