Primary biliary cholangitis in Spain. Results of a Delphi study of epidemiology, diagnosis, follow-up and treatment

Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva
Albert ParésAlicia Gil

Abstract

primary biliary cholangitis (PBC) is a rare disease with limited data regarding its epidemiology and standard clinical management in Spain. to gain insight into the epidemiology, patient flow, diagnosis, follow-up and treatment of PBC in Spain. a review of the literature and Delphi study involving 28 specialists in two rounds of consultations and an in-person results validation workshop. there are approximately 9,400 patients with PBC in Spain, with an annual incidence of 0.51-3.86 cases/100,000 population. Albeit, a high error margin may be presumed due to the scarcity of relevant studies on this subject. Several months may elapse from suspicion to a confirmed diagnosis, usually by a gastroenterologist or hepatologist. The role of the liver biopsy for diagnosis and follow-up is heterogeneous. Overall, 95% of patients are treated with ursodeoxycholic acid (UDCA) and response is primarily monitored using the Barcelona criteria. Follow-up is performed every six months, with a heterogeneous use of the various available techniques. No recommendations or second-line commercial drugs are available in the case of no response, inadequate response or intolerance to UDCA. while epidemiology may be estimated based on expert opinions, nati...Continue Reading

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Citations

Jul 10, 2021·Canadian Journal of Gastroenterology & Hepatology·Jakub GazdaPeter Jarcuska

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