PMID: 6112603Jun 13, 1981Paper

Primary biliary cirrhosis--a revised clinical spectrum

Lancet
O F JamesA J Watson

Abstract

The presentation or method of detection of 93 patients with primary biliary cirrhosis (PBC) from Northern England is reported. Almost half (45/93) the patients had no symptoms of liver disease when PBC was diagnosed; in many of them serum antimitochondrial activity (AMA) was detected during immunological screening for other diseases. 13 patients with normal liver function tests had symptomless PBC. Liver histology in 6 of these was diagnostic for PBC, and 7 had histology suggestive of PBC; all had a positive AMA titre greater than or equal to 1/40. The mortality of the symptom-free AMA-positive patients over a mean follow-up of 4-5 years did not differ from that of the general population. Only 1 out of 45 initially symptom-free patients died in the follow-up period (8 months-12 years). 37 patients had disorders which may be associated with PBC--including 16 with thyroid disease, 9 with rheumatoid arthritis, and 5 with mixed connective tissue disease. It is suggest that, as with autoimmune thyroid disease, overt organ damage never develops in many patients with symptomless PBC.

References

Dec 1, 1977·Clinical Endocrinology·W M TunbridgeP A Smith
Sep 27, 1973·The New England Journal of Medicine·S Sherlock, P J Scheuer
Jan 1, 1968·Journal of Clinical Pathology·G S FellR A Howie

❮ Previous
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Citations

Jul 1, 1987·Digestive Diseases and Sciences·T OkunoT Takino
Jan 1, 1991·Immunologic Research·U Hopf, R Stemerowicz
Jun 1, 1986·Irish Journal of Medical Science·D KelleherC Feighery
Oct 21, 2006·Digestive Diseases and Sciences·Jayant A TalwalkarKeith D Lindor
Jul 1, 1992·Journal of Dermatological Science·A ReboraF Rongioletti
Dec 21, 2000·Clinical and Experimental Immunology·J M PalmerD E Jones
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S P FusseyS J Yeaman
Nov 1, 1993·Journal of Internal Medicine·T TanusB Zweiman
Sep 1, 1990·Journal of Gastroenterology and Hepatology·C Y ChanK J Lo
Jun 1, 1982·Annals of the Rheumatic Diseases·P R Mills, R D Sturrock
Jun 26, 1982·British Medical Journal·D R Triger
May 11, 1996·BMJ : British Medical Journal·J V MetcalfR Bhopal
Oct 1, 1982·Gut·D R TrigerA M Ward
Nov 1, 1986·Gut·M R LuceyR Williams
Sep 1, 1991·Gut·J NeubergerR Galbraith
Aug 1, 1989·Postgraduate Medical Journal·A K BurroughsK Rolles
Mar 23, 2000·Postgraduate Medical Journal·M I Prince, D E Jones
Apr 1, 2005·Treatments in Endocrinology·Vahab Fatourechi
Jun 6, 2008·World Journal of Gastroenterology : WJG·Andrea CrosignaniMauro Podda
May 6, 2008·Clinics in Liver Disease·Teru Kumagi, Morikazu Onji
May 6, 2008·Clinics in Liver Disease·Julia L Newton
Jul 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L R RubelB A Cuccherini
Jul 20, 2007·The Cochrane Database of Systematic Reviews·Y GongC Gluud
Apr 12, 2005·QJM : Monthly Journal of the Association of Physicians·J KurtovicR Williams
Nov 20, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Einar BjörnssonRoberta Jorgensen
May 14, 2010·The Cochrane Database of Systematic Reviews·Vanja GiljacaChristian Gluud
Oct 1, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Géraldine DahlqvistUNKNOWN French network of Immunology Laboratories
Apr 24, 2004·The Cochrane Database of Systematic Reviews·Y Gong, C Gluud
Jul 20, 2007·The Cochrane Database of Systematic Reviews·Y GongC Gluud

❮ Previous
Next ❯

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