PMID: 9556352Jan 1, 1997Paper

Primary biliary cirrhosis an epithelitis: evidence of abnormal salivary gland immunohistochemistry

Autoimmunity
K TsuneyamaM Eric Gershwin

Abstract

Primary biliary cirrhosis (PBC) is an autoimmune liver disease of unknown etiology. Nearly 93% of patients with PBC exhibit evidence of focal sialoadenitis. In an earlier study, we reported evidence of aberrant expression of PDC-E2, or a mimeotope, in the salivary glands of patients with PBC that had Sjogren's syndrome. At the time of the previous study, data was not yet available regarding patients with PBC without sicca complaints. Therefore, to investigate the extent of salivary gland involvement in PBC, we collected lip biopsy sections from 9 PBC patients diagnosed as PBC by liver biopsy, without clinical or histologic features of Sjogren's syndrome and 9 PBC patients with established Sjogren's syndrome. Using immunohistochemical staining with both a murine monoclonal antibody. C355.1, and a human combinatorial antibody, SP4, we examined the ducts of these salivary glands for the presence of the characteristic aberrant staining pattern found in patients with PBC. We report that 6/9 PBC patients fulfilling established Sjogren's syndrome criteria and 6/9 PBC patients lacking features of Sjogren's syndrome showed intense staining of the ductal epithelial cells of the salivary gland. These data suggest that the PBC-specific ant...Continue Reading

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Citations

Jul 30, 2009·Odontology·Joel J NapeñasPhilip C Fox
Aug 29, 2006·Digestive Diseases and Sciences·Jordan J FeldE Jenny Heathcote
Feb 20, 2002·Journal of Gastroenterology and Hepatology·N IkunoM J Rowley
May 2, 2002·Journal of Gastroenterology and Hepatology·Atsushi HokariGotaro Toda
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M SasakiM E Gershwin
Jan 23, 1999·Current Opinion in Rheumatology·J Braun, J Sieper
Mar 25, 2015·International Journal of Molecular Sciences·Jun GaoBingyuan Wang
Nov 3, 2015·Expert Review of Gastroenterology & Hepatology·Ahmad H AliKeith D Lindor
Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S Reynoso-PazM E Gershwin
Mar 24, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Inger von BültzingslöwenMorten Schiødt
Feb 16, 2015·Clinical Reviews in Allergy & Immunology·Ying SunM Eric Gershwin
Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A TanakaM E Gershwin
Feb 22, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Nikolaos K GatselisGeorge N Dalekos
Dec 15, 2020·Lancet·Ana LleoGideon M Hirschfield

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