PMID: 6103987May 31, 1980Paper

Primary biliary cirrhosis is a dry gland syndrome with features of chronic graft-versus-host disease

Lancet
O EpsteinS Sherlock

Abstract

Primary biliary cirrhosis (PBC) is part of a disease complex characterised by dry eyes, dry mouth, and both biliary and pancreatic hyposecretion: it is a "dry gland" syndrome resulting from damage to ductular epithelium. Additional extraglandular features include scleroderma-like skin lesions, pigmentation, Raynaud phenomenon and severe abnormalities of both humoral and cellular immunity. Identical ductular and extraductal features, including abnormalities of the immune system, are seen in chronic graft-versus-host disease after bone-marrow transplantation. It is suggested that in PBC the ductular lesions and severe disturbance of the immune system including macroglobulinaemia and immune complex formation occur as a result of an immune response to the histocompatibility (HC) complex antigens which are present in high density on ductular epithelial cells of the biliary tree. This response could be caused by altered antigenicity of epithelial cell HC antigens or by failure of the HLA-dependent T cell self-recognition system.

References

Dec 1, 1977·Annals of Internal Medicine·A A GratwohlA B Deisseroth
Dec 1, 1977·Annals of Internal Medicine·T J LawleyA B Deisseroth
Apr 1, 1979·The American Journal of Medicine·P R Graze, R P Gale
Jun 28, 1975·Lancet·P C Doherty, R M Zinkernagel
Dec 17, 1977·Lancet·H C ThomasS Sherlock
Apr 24, 1975·The New England Journal of Medicine·E D ThomasC D Buckner
Feb 1, 1978·Annals of the Rheumatic Diseases·A K ClarkeR Williams
Jun 1, 1979·Postgraduate Medicine·F Schaffner
Feb 2, 1978·The New England Journal of Medicine·J R WandsK J Isselbacher
Feb 14, 1974·The New England Journal of Medicine·R S Schwartz
Jul 1, 1973·Annals of Internal Medicine·D Alarcón-SegoviaE Fishbein
Nov 7, 1970·British Medical Journal·P L GoldingE Taylor
Jan 1, 1967·Gastroenterologia·M HradskýO Keller
Nov 26, 1964·The New England Journal of Medicine·F PARONETTOH POPPER

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Citations

Jan 1, 1982·Virchows Archiv. A, Pathological Anatomy and Histopathology·Y NakanumaK Kobayashi
Oct 1, 1986·Klinische Wochenschrift·P A Berg, R Klein
Dec 1, 1980·Springer Seminars in Immunopathology·H Popper, F Paronetto
Dec 1, 1980·Springer Seminars in Immunopathology·H C Thomas, O Epstein
Jan 1, 1991·Immunologic Research·U Hopf, R Stemerowicz
Oct 1, 1985·Irish Journal of Medical Science·F ShanahanJ Crowe
Jan 1, 1985·Molecular Aspects of Medicine·I G McFarlane
Jan 1, 1985·Molecular Aspects of Medicine·O Epstein
Mar 1, 1989·Journal of Hepatology·A FloreaniO F James
Jul 1, 1987·Baillière's Clinical Gastroenterology·P A Berg, R Klein
Jul 26, 1980·Lancet·J L Waddington, A J Cross
Nov 7, 1981·Lancet·D A MahoneyG Thatcher
Oct 1, 1983·Lancet·S Sherlock
Nov 30, 2000·Journal of Hepatology·C CorpechotR Poupon
Jan 1, 1986·Journal of Hepatology·Y Nagafuchi, P J Scheuer
Aug 1, 1985·Journal of the American Academy of Dermatology·D J HoganP R Lane
Oct 1, 1983·Clinics in Haematology·K M Sullivan, R Parkman
Feb 26, 2000·International Journal of Dermatology·C M Magro, A N Crowson
Feb 20, 2002·Journal of Gastroenterology and Hepatology·T TakahashiH Asakura
Feb 20, 2002·Journal of Gastroenterology and Hepatology·N IkunoM J Rowley
Jul 18, 2002·ANZ Journal of Surgery·Mehrdad NikfarjamDavid Clouston
Jan 7, 1982·The New England Journal of Medicine·J NeubergerR Williams
Jan 7, 1982·The New England Journal of Medicine·E A Jones
Jun 1, 1982·The British Journal of Dermatology·R A Graham-BrownS Sherlock
Dec 1, 1996·International Journal of Dermatology·H TabataS Yamazaki
Jun 1, 1982·Annals of the Rheumatic Diseases·P R Mills, R D Sturrock
Nov 1, 1985·The British Journal of Ophthalmology·A GiovanniniF B Bianchi
Jul 1, 1985·Journal of Clinical Pathology·F CassaniE Pisi
Dec 21, 2000·Clinical and Experimental Immunology·P InvernizziM Podda
Sep 7, 2007·Annals of the New York Academy of Sciences·Atsushi TanakaHajime Takikawa

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