PMID: 9643664Jun 27, 1998Paper

Primary bladder carcinoma in situ: assessment of early BCG response as a prognostic factor

European Urology
A OrsolaJ Vicente

Abstract

To evaluate the prognosis of primary bladder carcinoma in situ (CIS) according to the response to bacillus Calmette-Guerin (BCG). Twenty-six cases of primary CIS were treated with BCG. Mean, median and minimum follow-up periods were 47, 56 and 24 months. At 6 months, the patients were evaluated endoscopically and the response was classified as complete, partial or failure. Twenty-one patients (80.8%) showed complete response to BCG, 3 did so after a second course; 28.5% relapsed or progressed at a mean of 44 months. Five patients (19.2%) did not respond initially and all progressed in a period of 6 months. Early response to BCG was the only significant prognostic factor (p < 0.005). A high- and a low-risk group of bladder CIS can be differentiated according to the response to BCG. CIS of the bladder has a poor prognosis, and the number of patients who developed progressive disease is significantly higher among the nonresponders.

Citations

Apr 3, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Atsushi TakenakaMasato Fujisawa
Dec 21, 2004·Expert Review of Anticancer Therapy·Wassim Kassouf, Ashish M Kamat
Dec 1, 1999·Current Opinion in Urology·A Böhle, C Durek
Jun 27, 2002·Current Urology Reports·A M Kamat, D L Lamm
Jul 10, 2004·International Journal of Urology : Official Journal of the Japanese Urological Association·Alessandro SciarraFranco Di Silverio
Dec 17, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Yasuhisa Fujii
Feb 25, 2000·Urology·A M Kamat, D L Lamm
Dec 25, 2007·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·Jacques IraniChristine Theodore

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