Primary bone cancer in Leonbergers may be associated with a higher bodyweight during adolescence

Preventive Veterinary Medicine
Kristin P AnfinsenThora J Jonasdottir

Abstract

Weight-bearing stress may be a risk factor for both human and canine primary bone cancer. A cohort of Leonbergers (LB) was followed from birth to death and the cause of death recorded. We hypothesised that dogs dying due to primary bone cancer would be larger; measured by bodyweight (BW) and the circumference of the distal radius and ulna (CDRU) than those of the same breed that died of other causes. Information obtained from breeders, owners and veterinary surgeons were questionnaire-based. The dogs were examined by a veterinary surgeon at pre-specified "observational ages" (3, 4, 6, 12, 18, and 24 m). Data were recorded, including BW and CDRU. The study population consisted of 196 LB, 9 of which died due to primary bone cancer (6 males, 3 females). Individual growth curves, showing BW and CDRU during the first 2 years of life, were made for these 9 dogs and compared to gender-specific mean values for LB that died from other causes. These curves showed that LB succumbing to primary bone cancer generally had a higher BW during the growth period than the remaining dogs, and that this difference appeared to be largest in the male LB. Male LB that developed primary bone cancer later in life also had a larger CDRU during most part ...Continue Reading

References

Jan 1, 1995·Cancer·H D Dorfman, B Czerniak
Aug 6, 1998·The Veterinary Journal·G RuL T Glickman
Oct 6, 2007·Journal of the American Veterinary Medical Association·Julie A RosenbergerP Cynda Crawford
Oct 20, 2010·Preventive Veterinary Medicine·Randi I KrontveitCathrine Trangerud
Feb 22, 2011·Cancer Causes & Control : CCC·Ramandeep S AroraJillian M Birch
Apr 6, 2011·Cancer Causes & Control : CCC·Lisa MirabelloSharon A Savage

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