Primary Campylobacter jejuni infection in different mice strains

Microbial Pathogenesis
Darinka VuckovićM Dorić

Abstract

Campylobacter jejuni is one of the most frequent causes of diarrhoea in man. Extra-intestinal manifestations may also occur, particularly in immunocompromised individuals. However, because of the lack of appropriate animal models the pathophysiology and immunological response of the host to C. jejuni infection are still poorly understood. In our laboratory an experimental infection of adult BALB/c, C57BL/6 and DBA/2 mice has been established. After intraperitoneal injection of 0.5-1x10(9) cfu of C. jejuni none of the infected mice showed clinical symptoms of illness, but bacterial spreading and tissue invasion were achieved. We have concentrated our studies on the duration of primary infection, recovery of bacteria from livers and spleens of infected animals and pathohistological changes of these organs. Our results showed differences in the course of systemic infection among the tested mice strains. BALB/c mice were most sensitive, resulting in the most pronounced pathohistological changes in the examined organs. The duration of the primary liver infection was the longest in BALB/c mice while the duration of the splenic infection also differed among the tested mice strains. Nevertheless, the experimental model used in this stu...Continue Reading

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Citations

Feb 24, 2001·Mediators of Inflammation·M AbramM Dorić
May 4, 2013·Foodborne Pathogens and Disease·Anja KlančnikSonja Smole Možina
May 7, 2003·Applied and Environmental Microbiology·Philip F MixterMichael E Konkel
Jan 5, 2008·Infection and Immunity·Nicole M IovineYvette Weinrauch
Dec 22, 2005·Infection and Immunity·Franca R JonesStephen E Walz
Dec 6, 2008·World Journal of Gastroenterology : WJG·Rune AabenhusAsa Ljungh
Jun 4, 2015·Virulence·Anja KlančnikDarinka Vučković
Jul 9, 2004·Journal of Applied Microbiology·G D InglisH W Busz
Aug 23, 2006·FEMS Microbiology Letters·Erica S RinellaDeborah S Threadgill
May 30, 2009·Research in Microbiology·Anja KlancnikSonja Smole Mozina
Oct 3, 2014·Microbes and Environments·Anja KlančnikSonja Smole Možina
Mar 22, 2003·FEMS Immunology and Medical Microbiology·Maja AbramMartina Deckert
Jan 19, 2008·Journal of Medical Microbiology·Nadia A Al-BannaM John Albert
Apr 10, 2010·Journal of Food Protection·N HaddadJ-M Cappelier

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Campylobacteriosis is caused by the bacteria Campylobacter jejuni and is a common cause of gastroenteritis in humans. Discover the latest research on Campylobacteriosis here.

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