Primary capillary hemangioblastoma of peripheral soft tissues

The American Journal of Surgical Pathology
Michal MichalKarep Koudepa

Abstract

A case of capillary hemangioblastoma located in the peripheral soft tissue of the inner ankle in a 74-year-old woman is presented. The tumor was an unencapsulated but sharply circumscribed nodule 2.5 cm in size, of a yellow-white color. It showed reddish-brown spots with small cysts up to 2 mm filled with blood. Grossly the tumor was not attached to any peripheral nerve. Signs of von Hippel-Lindau's disease were excluded by thorough clinical evaluation. No additional tumor or erythrocytosis was found in the patient clinically. Immunohistochemically, the tumor stromal cell reacted strongly with antibodies to S-100 protein, NSE, and calponin and they were negative with antibodies to GFAP, CD34, CD31, cytokeratins, actin, desmin, EMA, and HMB-45. Endothelium of the capillaries reacted positively with antibodies to CD31, CD34, and Factor VIII-related protein. Capillary pericytes were actin-positive. All cells of the tumor stained positively with antibody to vimentin. MIB1 antibody reacted only in very few cells (<1%). Ultrastructurally, the stromal cells contained electron-lucent cytoplasm with lipid droplets, a small amount of rough endoplasmic reticulum, and glycogen particles. No electron-dense structures typical of secretory gr...Continue Reading

References

Jul 1, 1991·Neurosurgery·N ZecJ Towfighi
Jan 1, 1985·Clinical Neurology and Neurosurgery·J G WolbersW Kamphorst
Mar 1, 1984·Ophthalmology·P Hardwig, D M Robertson
Jan 1, 1995·Neurosurgery·J A BrodkeyT F O'Brien
May 1, 1994·Nature Genetics·J R GnarraF M Duh
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·J G HermanW M Linehan
Jan 23, 1999·Neurosurgery·R E TibbsF A Raila
Apr 13, 2000·Annals of Diagnostic Pathology·J C Fanburg-SmithL D Thompson
Apr 20, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·S GläskerH P Neumann
Sep 1, 1959·The British Journal of Surgery·A V BIRD, H MENDELOW
Oct 21, 1961·JAMA : the Journal of the American Medical Association·L A CHRISTOFERSONA G PETERSEN

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Citations

Sep 27, 2007·The American Journal of Surgical Pathology·Daisuke NonakaJuan Rosai
Oct 7, 2010·The American Journal of Surgical Pathology·Yiu-Tung IpJohn K C Chan
Jul 24, 2015·Journal of Clinical Pathology·Yong WuChao-Fu Wang
Oct 18, 2005·Human Pathology·Kurt T PattonWilliam B Laskin
Jan 13, 2015·Case Reports in Pathology·Li LuAnthony T Yachnis
Jul 10, 2008·International Journal of Surgical Pathology·John PanelosAlessandro Franchi
Dec 1, 2017·Advances in Anatomic Pathology·Michele BiscegliaCarlos E Bacchi
Nov 21, 2008·Virchows Archiv : an International Journal of Pathology·M MichalM Hora
Jan 9, 2020·The American Journal of Surgical Pathology·Kaleigh E Lindholm, Cesar A Moran
Feb 13, 2013·Advances in Anatomic Pathology·Giovanni FalconieriSaul Suster
Mar 22, 2013·International Journal of Surgical Pathology·Andrea Casadei GardiniGiovanni Luca Frassineti
May 4, 2010·Applied Immunohistochemistry & Molecular Morphology : AIMM·Akihiko YoshidaHitoshi Tsuda
Apr 27, 2021·The American Journal of Surgical Pathology·Abbas AgaimyCristina R Antonescu

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