Primary cardiac lymphoma: molecular cytogenetic characterization of a rare entity

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Andrew J SchellHarriet Feilotter

Abstract

The majority of cardiac atrial neoplasms represent benign myxomas. Rarely, malignant cardiac neoplasms are encountered and can include primary cardiac neoplasms, as well as secondary tumors involving the heart. As many cardiac neoplasms lack pathognomonic clinical features, histopathologic diagnosis is crucial for classification and appropriate treatment of these neoplasms. Molecular investigation is critical to begin to catalogue genomic changes that correlate with these malignancies. A 60-year-old man presented with superior vena cava syndrome, and computed tomographic scan revealed an infiltrative mass of the right atrium that nearly filled the atrial chamber and partially occluded superior vena cava flow. Urgent surgical resection revealed a soft mass with the appearance of "fish flesh." Histologic, immunochistochemical, cytogenetic, and detailed molecular investigations were carried out. Histologic examination revealed complete replacement of the atrial wall by diffuse sheets of pleomorphic lymphoid cells with occasional smaller plasmacytoid cells. The predominant lymphoid population was immunoreactive for CD45, CD20, CD79a, BCL-2, BCL-6, Ki-67, CD10, p53, and light chain restricted for IgM lambda. A diagnosis of primary c...Continue Reading

References

Nov 14, 2000·American Journal of Hematology·J KurodaM Kondo
Jun 21, 2002·The New England Journal of Medicine·Andreas RosenwaldUNKNOWN Lymphoma/Leukemia Molecular Profiling Project
Feb 26, 2004·Nature Genetics·Adrian S IshkanianWan L Lam
Nov 30, 2005·European Journal of Haematology·Z Y LimA Pagliuca
Dec 24, 2005·Pathology·Lynda J Campbell
Aug 28, 2007·The American Journal of Surgical Pathology·Alessandra F NascimentoGeraldine S Pinkus

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Citations

Oct 2, 2012·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Giovanni BartoloniVincenzo Canzonieri
Sep 7, 2018·Leukemia & Lymphoma·Natalia Cichowska-CwalińskaRenata Zaucha
Jul 19, 2021·Annales de cardiologie et d'angéiologie·I TaziF Z Lahlimi

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