Primary cardiac osteosarcoma with recurrent episodes and unusual patterns of metastatic spread

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Anil V ParwaniUma N M Rao

Abstract

Primary osteosarcoma of the heart is an extremely rare entity. In this report, we describe a case of primary osteosarcoma of the heart that recurred and metastasized. The patient is a 50-year-old woman who presented with an abrupt onset of dyspnea, dizziness, and palpitations. Echocardiography results showed a left atrial tumor that was resected and had histological features of high-grade osteosarcoma. The patient was treated with adjuvant chemotherapy. The tumor recurred in the same location 4 years later and was resected. Three years later, the patient presented with a 4-cm polypoid mass in the stomach that was consistent with metastatic osteosarcoma. One year later, the patient presented with recurrent high-grade sarcoma in the soft tissue of the left chest wall. We herein present the spectrum of histological findings and molecular genotyping data.

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Citations

Mar 26, 2013·General Thoracic and Cardiovascular Surgery·Andrea Dell'AmoreFranco Stella
Feb 26, 2016·Heart, Lung & Circulation·Ji-Gang WangXiu-Ping Liu
Oct 7, 2008·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Maria Carmen Gomez-RubinJose Lopez-Sendon
Jun 4, 2020·Therapeutic Advances in Medical Oncology·Milena UrbiniMaristella Saponara
Nov 26, 2010·Interactive Cardiovascular and Thoracic Surgery·Ziyin YeAnjia Han
Nov 10, 2017·International Heart Journal·Yi LuoXijun Xiao
Jan 14, 2010·Current Opinion in Pediatrics

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