Primary care screen for early dementia

Journal of the American Geriatrics Society
Ellen GroberJeanne A Teresi

Abstract

To determine whether the Alzheimer's Disease Screen for Primary Care (ADS-PC) is more sensitive to early dementia than the Mini-Mental State Examination (MMSE) and whether it has as high a misclassification rate in minority patients and patients with limited education. Cross-sectional validation study. Urban geriatric primary care practice. Three hundred sixteen African-American and Caucasian patients, including 55 patients with early dementia (Clinical Demential Rating of 0.5). The ADS-PC is a two-stage strategy for identifying early dementia that consists of a brief high-sensitivity dementia screen, applied to all patients aged 65 and older, and a second stage to identify memory impairment, applied to patients who fail the first stage. Differences in the sensitivities or specificities of the ADS-PC and the MMSE were evaluated using the McNemar test. Receiver operating characteristic curves were used to examine differences in the operating characteristics of the ADS-PC across a range of cutscores. When the specificities of both tests were equated (0.90), the sensitivities were significantly different (ADS-PC, 0.75; MMSE, 0.56). The MMSE failed to identify five times as many cases of dementia as the ADS-PC. When the sensitiviti...Continue Reading

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Citations

Apr 11, 2013·The Journal of Behavioral Health Services & Research·Yolonda R PickettWilliam Woolis
Oct 29, 2008·Journal of the International Neuropsychological Society : JINS·Beth E SnitzJudith A Saxton
Aug 9, 2008·Age and Ageing·Maneesha Lakmalie De SilvaGraeme David Hammond-Tooke
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Nov 14, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Hideki OkamotoTakao Namiki
Oct 1, 2011·Journal of Primary Care & Community Health·Ellen GroberRichard B Lipton
Jan 1, 2012·Journal of Primary Care & Community Health·Ellen GroberRichard B Lipton
Aug 15, 2014·Journal of the International Neuropsychological Society : JINS·Ellen GroberRichard B Lipton
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May 6, 2008·Journal of the American Geriatrics Society·Ellen GroberRichard B Lipton
Nov 5, 2010·Journal of the American Geriatrics Society·Anne B Newman
Dec 24, 2009·Statistics in Medicine·Cuiling Wang, Charles B Hall
Jun 9, 2016·Journal of Clinical and Experimental Neuropsychology·Ellen GroberRichard B Lipton
Dec 17, 2008·Journal of the American Medical Directors Association·Daniel I KauferPhilip D Sloane
Jul 12, 2013·Medicine, Science, and the Law·Claudio TerranovaCarmelo Militello
Dec 15, 2007·Journal of the International Neuropsychological Society : JINS·Ellen GroberRichard B Lipton

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