Primary care use of FRAX: absolute fracture risk assessment in postmenopausal women and older men

Postgraduate Medicine
Ethel S SirisAurelia Nattiv

Abstract

Osteoporosis-related fractures (low-trauma or fragility fractures) cause substantial disability, health care costs, and mortality among postmenopausal women and older men. Epidemiologic studies indicate that at least half the population burden of osteoporosis-related fractures affects persons with osteopenia (low bone density), who comprise a larger segment of the population than those with osteoporosis. The public health burden of fractures will fail to decrease unless the subset of patients with low bone density who are at increased risk for fracture are identified and treated. Risk stratification for medically appropriate and cost-effective treatment is facilitated by the World Health Organization (WHO) FRAX algorithm, which uses clinical risk factors, bone mineral density, and country-specific fracture and mortality data to quantify a patient's 10-year probability of a hip or major osteoporotic fracture. Included risk factors comprise femoral neck bone mineral density, prior fractures, parental hip fracture history, age, gender, body mass index, ethnicity, smoking, alcohol use, glucocorticoid use, rheumatoid arthritis, and secondary osteoporosis. FRAX was developed by the WHO to be applicable to both postmenopausal women an...Continue Reading

References

Feb 7, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A C LookerS P Heyse
Dec 16, 1998·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A C LookerR Lindsay
May 18, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A OdenJ A Kanis
Jun 15, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P Dargent-MolinaG Bréart
Feb 15, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy
Aug 31, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D M BlackO Johnell
Jul 12, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisUNKNOWN National Osteoporosis Foundation
May 6, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·John A KanisDan Mellstrom
May 26, 2004·Archives of Internal Medicine·Ethel S SirisMarc L Berger
Jun 4, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisA Tenenhouse
Sep 30, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·John A KanisAlan Tenenhouse
Dec 24, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·John A KanisNikolai Khaltaev
Feb 25, 2005·The Journal of Clinical Endocrinology and Metabolism·Stacey A WainwrightUNKNOWN Study of Osteoporotic Fractures Research Group
Sep 15, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elisabeth Sornay-RenduPierre D Delmas
Jan 5, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E S SirisY-T Chen
May 16, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A PascoM A Kotowicz
Sep 26, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Steven R CummingsUNKNOWN Study of Osteoporotic Fractures Research Groups
Oct 18, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Eugene V McCloskeyJohn A Kanis
Feb 27, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisN Yoshimura
Apr 28, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y-T ChenE S Siris
Jun 1, 2007·The New England Journal of Medicine·Sundeep Khosla, L Joseph Melton
Oct 10, 2007·Archives of Internal Medicine·Sarah D BerryDouglas P Kiel
Jan 19, 2008·BMJ : British Medical Journal·Teppo L N JärvinenPekka Kannus
Feb 16, 2008·BMJ : British Medical Journal·Jonathan Bayly, Tahir Masud
Feb 23, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B Dawson-HughesUNKNOWN National Osteoporosis Foundation Guide Committee
Feb 23, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A N A TostesonUNKNOWN National Osteoporosis Foundation Guide Committee
Feb 23, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisE McCloskey
Mar 6, 2008·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jeffrey StroupAsim M Abu-Baker
May 8, 2008·Current Rheumatology Reports·Zoe A ColeCyrus Cooper
Nov 13, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E V McCloskeyJ A Kanis
Dec 4, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Meghan G DonaldsonUNKNOWN Study of Osteoporotic Fractures
Jan 14, 2009·Southern Medical Journal·E Michael Lewiecki, Nelson B Watts
Feb 7, 2009·Bone·John A KanisEugene McCloskey
Apr 15, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nelson B WattsMeryl S LeBoff
May 8, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Meghan G DonaldsonSteven R Cummings
Aug 26, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B Dawson-HughesL J Melton
Aug 26, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B EttingerL J Melton

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Citations

Feb 1, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W Pluskiewicz, B Drozdzowska
May 26, 2012·Chiropractic & Manual Therapies·John Am Taylor, André Bussières
Jun 10, 2014·Indian Journal of Endocrinology and Metabolism·Partha Pratim ChakrabortySanjay Kalra
Jun 22, 2010·Current Osteoporosis Reports·Joop P W van den BerghPiet P Geusens
Jul 10, 2013·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Laura Hanson
Mar 1, 2012·Climacteric : the Journal of the International Menopause Society·Amos Pines
Jan 20, 2016·Archives of Osteoporosis·Selim SanelCan Solakoglu
Jan 20, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W B KatzmanK Shipp
Sep 25, 2015·Calcified Tissue International·Melissa M Formosa, Angela Xuereb-Anastasi
Aug 20, 2011·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Nithya SettyJulie Glowacki
Sep 14, 2015·Oral and Maxillofacial Surgery Clinics of North America·Stuart Weinerman, Gianina L Usera
May 20, 2015·Acta Clinica Belgica·M SnackenT Pepersack
Apr 18, 2012·Cancer·Kerri M Winters-StoneKristin L Campbell
Jan 7, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Fredrik DetterMagnus K Karlsson
Sep 12, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J FritzM K Karlsson
Dec 31, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·José Antonio Martínez PérezMaite Pérez
Mar 7, 2013·Orvosi hetilap·Mátyás FehérváriZoltán Szeberin
Jan 25, 2014·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Wojciech PluskiewiczBogna Drozdzowska
Nov 26, 2016·Best Practice & Research. Clinical Rheumatology·Helen SlaterAndrew M Briggs
Dec 20, 2011·Scottish Medical Journal·F R MacLeanS J Gallacher
Jun 3, 2011·The Journal of Rheumatology·Elisabetta RomagnoliSalvatore Minisola
Apr 23, 2013·International Journal of Endocrinology·Nicole YurginMarc Hochberg
Aug 28, 2012·Menopause : the Journal of the North American Menopause Society·Tommaso Simoncini, Andrea R Genazzani
May 30, 2020·International Journal of Environmental Research and Public Health·Agnieszka Nawrat-SzołtysikAnna Polak
Jun 27, 2019·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Jaskirat S TakharJohn A Gonzales
Apr 23, 2021·International Urology and Nephrology·Betul CetinEbru Asicioglu

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