PMID: 30143499Aug 26, 2018Paper

Primary Central Nervous System Lymphoma with Associated Demyelination and Creutzfeldt Astrocytes

Annals of Clinical and Laboratory Science
Hanadi El AchiLeomar Y Ballester

Abstract

A previously healthy 54-year-old woman presented with weight loss, progressive weakness that was more pronounced on the left side, and intermittent occipital headaches. Imaging studies showed multiple enhancing lesions along the white matter, compatible with a demyelinating process. The patient's previous history included relapsing-remitting symptoms of weakness over the past 3 years. A stereotactic brain biopsy showed histological features of demyelination with an associated population of neoplastic lymphoid cells. These unusual findings raise the question of whether demyelinating disease preceded the development of primary CNS lymphoma (PCNSL), or whether PCNSL induced demyelination. Although rare, cases of "sentinel lesions" heralding the diagnosis of PCNSL have been reported. This case emphasizes the importance of having a high index of suspicion of PCNSL in the setting of suspected demyelinating lesion in an adult patient.

Related Concepts

Related Feeds

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
Leila HusseiniBernd C Kieseier
Journal of Neurology, Neurosurgery, and Psychiatry
K BrecherP Riskind
Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Steven NgChristopher Rowe
Acta clinica Croatica
Vanja Basić KesVida Demarin
© 2022 Meta ULC. All rights reserved