Primary central nervous system lymphoma: immunohistochemical profile and prognostic significance

Neuropathology : Official Journal of the Japanese Society of Neuropathology
Delphine RaouxMichel Péoc'h

Abstract

Primary central nervous system lymphoma (PCNSL) is a rare subtype of non-Hodgkin lymphoma (NHL) with extranodal location affecting only the CNS, meninges and eye, without visceral or lymph node involvement. Its incidence has increased sharply over the past three decades, especially in immunocompetent subjects. Most PCNSL cases are diffuse large B-cell lymphomas (DLBCLs). However, it differs from nodal DLBCL in that it has a worse prognosis. DLBCLs are a heterogeneous entity and according to new genomic discoveries, classifications into prognostic subgroups have been embarked upon. Two prognostic algorithms were then prepared using a panel of immunohistochemical markers (CD10, Bcl6, MUM1/IRF-4, and Bcl2), thus categorizing DLBCL into two subgroups, GCB (germinal centre B-cell-like) or non-GCB, and into Group 1 or Group 2. Our goal is to apply both of these two sub-classifications to 39 PCNSLs, in order to assess their usefulness and prognostic relevance. 74.3% of our PCNSLs were of a non-GCB phenotype, corresponding to an activated postgerminal origin. They were evenly distributed across G1 and G2. Two- and 5-year overall survival rates were 34.8% and 19.6%, respectively. Younger age (<65) and a therapeutic combination of chemot...Continue Reading

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Citations

Aug 13, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Keiji TsutsumiKazuhiro Hongo
Aug 5, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Uiju ChoYoun Soo Lee
Oct 25, 2017·The Journal of Craniofacial Surgery·Evin Singar OzdemirAslihan Yavas Can
Aug 5, 2017·Chinese Medical Journal·Xue-Liang Yang, Yuan-Bo Liu
Oct 9, 2019·Current Opinion in Neurology·K Grace Ho, Christian Grommes
Oct 1, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Seung-Myoung SonYoung-Hyeh Ko
Aug 15, 2014·Journal of Neuro-oncology·Bum-Joo Cho, Hyeong Gon Yu
Dec 31, 2019·Journal of Neuropathology and Experimental Neurology·Csaba BödörLilla Reiniger
Oct 12, 2018·Annals of Hematology·Anahita NosratiSajjadeh Movahedinia
Dec 20, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Chelsea MarcusHemant Varma
Oct 27, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Xinmin ZhangJian Yi Li

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