Primary central nervous system lymphomas in AIDS patients

Enfermedades infecciosas y microbiología clínica
Marcelo CortiMarina Narbaitz

Abstract

Primary lymphoma is the most common neoplasm of the central nervous system (CNS) in AIDS patients. We retrospectively reviewed the clinical manifestations, neuroimaging findings, diagnostic methods used, histological characteristics, detection of Epstein-Barr virus (EBV) DNA by PCR in cerebrospinal fluid (CSF) and brain smears, and outcome of 18 HIV/AIDS patients with primary CNS lymphoma. The overall incidence of primary CNS lymphoma was 2.6%. Fifteen were men and mean age was 33.6 years. The most frequent clinical findings were focal neurological deficits and seizures. The mean CD4 T cell count at the time of diagnosis was 44 cells/microl. Primary CNS lymphoma presented as single, large (> 2.5 cm) lesions in 14 patients (77.8%). All the lesions were associated with a mass effect and surrounding edema. EBV DNA was detected in nine brain smears. In seven of these nine cases, EBV DNA was also found in CSF by PCR. Median survival after specific diagnosis was 75 days. This study upholds a link between EBV and these tumors. Primary CNS lymphoma was associated with a poor prognosis and short survival in this cohort of patients.

Citations

Jul 27, 2007·Revista Da Sociedade Brasileira De Medicina Tropical·Marcelo CortiMarcela de Dios Soler
Mar 5, 2008·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Gentiana I WenzelTimo Stöver
Sep 3, 2005·Revista Do Instituto De Medicina Tropical De São Paulo·Marcelo CortiMarina Narbaitz
Sep 22, 2020·Pathology, Research and Practice·Raduan Ahmed FrancaMassimo Mascolo

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