Primary chemotherapy for clinical stage II nonseminomatous germ cell testicular tumors: selection criteria and long-term results

Mayo Clinic Proceedings
S E LernerH Zincke

Abstract

To determine the treatment option for patients with low-volume stage II nonseminomatous germ cell testicular tumors (NSGCTT) that yields the best survival, is associated with the least morbidity, and avoids "double therapy"--that is, chemotherapy and retroperitoneal lymph node dissection (RPLND). We reviewed our institutional experience with 28 patients with stage II NSGCTT who received primary chemotherapy between August 1983 and October 1992. The 28 study patients (mean age, 28 years; range, 20 to 52) with low-volume stage II NSGCTT were treated with bleomycin, etoposide, and cisplatin. The correlation of response rates with volume of disease and predominant histologic cell type was determined. The duration of survival was measured from the initiation of chemotherapy to the appearance of progressive disease or death or the date of last follow-up visit. Of the 28 patients treated, 27 (96%) achieved a complete response--20 (71%) with only chemotherapy and an additional 7 (25%) with chemotherapy plus surgical treatment. Twenty-seven patients (96%) remained free of disease after a median follow-up of 72 months. The most frequent complication was cisplatin-associated paresthesias or tinnitus which was noted in 13 patients (46%). I...Continue Reading

Citations

Aug 28, 2009·Nature Reviews. Rheumatology·Philip SongFrancesco Boin
Apr 14, 2011·Nature Reviews. Rheumatology·Aimee HershEd Yelin
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Apr 11, 2000·Cancer Control : Journal of the Moffitt Cancer Center·P Benedetto
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