PMID: 9537193Apr 16, 1998Paper

Primary chemotherapy in breast cancer: correlation between tumor response and patient outcome

American Journal of Clinical Oncology
J P FerrièrePhilippe Chollet

Abstract

This study focused on the correlation between tumor response and patient outcome in 329 breast cancers treated with primary chemotherapy. There were 141 stage IIIB tumors, including 109 inflammatory carcinomas. Other malignancies (34 IIIA, 99 IIB, 55 IIA) were operable but considered to be too large (> 3 cm) for conservative surgery and received primary chemotherapy to avoid mastectomy. All received the AVCF regimen, comprising 4-week cycles of doxorubicin (30 mg/m2) day 1, vincristine (1 mg/m2) day 1, 5-fluorouracil (5-FU; 400 mg/m2) days 2 through 5, cyclophosphamide (300 mg/m2) days 2 through 5. In 189 cases, methotrexate (15 mg/m2) was added at day 2 and day 3. Patients received 6 cycles, then underwent locoregional treatment (surgery, radiotherapy, or both) according to tumor regression. The response rate was assessed by clinical, mammographic, and echographic examinations: a 50% rate of objective responses were noted, of which 15% were complete responses (tumor shrinkage allowed breast conservation in 68% of patients who had stages II or IIIA). For the whole population studied, median follow-up was 111 months (range, 60- 196). One hundred fifty-seven patients had disease relapse (48 local, 14 contralateral, 95 distant). K...Continue Reading

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Citations

Dec 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A RingI E Smith
Nov 8, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Caroline RousseauMario Campone
May 27, 2016·Breast Cancer Research and Treatment·Ying L LiuEileen P Connolly
Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ian C SmithKeith N Ogston
Nov 1, 2002·Breast Cancer Research and Treatment·Hervé CuréPhilippe Chollet
Apr 12, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harry D BearNorman Wolmark
Oct 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harry D BearUNKNOWN National Surgical Adjuvant Breast and Bowel Project Protocol B-27
May 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Juliane HannemannMarc J van de Vijver
Feb 9, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Priya RastogiNorman Wolmark
Jan 26, 2006·Journal of Cancer Research and Clinical Oncology·David Aguiar BujandaJosé Aguiar Morales
Feb 6, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Simmyung YookRaymond M Reilly
Jul 6, 2010·The Journal of Surgical Research·Carlie R KennedyJulie A Margenthaler

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