Primary chemotherapy in operable breast cancer: eight-year experience at the Milan Cancer Institute

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
G BonadonnaM Zambetti

Abstract

Primary chemotherapy was administered to patients with tumors that measured > or = 2.5 cm in largest diameter to decrease the size of the primary tumor and allow for effective local and distant control while avoiding mastectomy. Two prospective nonrandomized studies were performed that used different regimens of primary chemotherapy followed by breast-sparing surgery in the presence of objective tumor remission. Additional postoperative chemotherapy was given to women at high risk of disease relapse. The median follow-up duration was 65 months. A total of 536 assessable patients were enrolled, and the main characteristics were fairly comparable between the two trials. Following primary chemotherapy, 85% of patients could be subjected to breast-sparing surgery; in 14 patients (3%), surgical specimens failed to show any residual neoplastic cell. In the final multivariate analysis, the histologically assessed extent of axillary node involvement (P < .001), as well as degree of response to primary chemotherapy (P = .034), represented the significant variables able to influence 8-year relapse-free survival. In women subjected to a breast-conserving approach, the cumulative risk of local relapse as first event alone was 6.8% (95% con...Continue Reading

Citations

Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G von MinckwitzM Kaufmann
Mar 11, 2000·Annals of Medicine·F Sapunar, I E Smith
Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I C SmithP F Sharp
Feb 16, 2002·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Tsuguhiro MiyashitaKazuo Shimizu
Mar 4, 2003·Breast Cancer Research and Treatment·Gudrun PohlMartin Filipits
Oct 24, 2003·Breast Cancer Research and Treatment·Margaretha RudasGudrun Pohl
Mar 6, 2004·Breast Cancer Research and Treatment·Laura MartincichMassimo Aglietta
Dec 22, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Véronique DiérasPierre Pouillart
May 10, 2005·Expert Review of Anticancer Therapy·Anwar R PadhaniAndreas Makris
May 24, 2005·AJR. American Journal of Roentgenology·Savannah C PartridgeNola M Hylton
Nov 3, 2005·Nature Clinical Practice. Oncology·Lajos Pusztai, Luca Gianni
Apr 12, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harry D BearNorman Wolmark
Sep 6, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W Fraser SymmansLajos Pusztai
Oct 7, 2008·Cancer·Nagi S El SaghirUNKNOWN Breast Health Global Initiative Systemic Therapy Focus Group
Aug 16, 2008·International Journal of Clinical Oncology·Tadahiko ShienTakayuki Kinoshita
Apr 7, 2009·Breast Cancer Research : BCR·Michael Untch, Gunter von Minckwitz
Mar 28, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Joan DuchFrancesca Pons
May 26, 2009·Medical Oncology·Malathy P V ShekharDaniel W Visscher
Mar 2, 2011·American Journal of Clinical Oncology·Christophe Le TourneauAnne Vincent-Salomon
Aug 26, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Silvia AntolínJesús García-Mata
Apr 18, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michail IgnatiadisChristos Sotiriou
Mar 14, 2012·Future Oncology·Akhil ChawlaElizabeth A Mittendorf
Apr 30, 2013·Breast Cancer Research : BCR·Paul M MeaneyKeith D Paulsen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
A N Papaioannou
© 2021 Meta ULC. All rights reserved