PMID: 20647663Jul 22, 2010Paper

Primary ciliary dyskinesia that responded to long-term, low-dose clarithromycin

Internal Medicine
Daisuke YoshiokaShigeru Kohno

Abstract

A 46-year-old man was referred to our hospital with hemoptysis. He had been diagnosed with chronic sinusitis since childhood, but had received no treatment. Chest CT showed a diffuse centrilobular granular shadow and thickened bronchial walls. Otitis media and decreased spermatic motor ability were identified. In addition, electron microscopy of a biopsy specimen of the nasal mucosa showed a deficiency of inner dynein. Based on these clinical findings, primary ciliary dyskinesia (PCD) was diagnosed and successfully treated with long-term, low-dose clarithromycin. Although the effects of macrolide therapy remain controversial, long-term treatment with low-dose clarithromycin might confer clinical benefits upon patients with PCD.

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Citations

Jul 23, 2013·Revue de pneumologie clinique·A Tamalet, S Blanchon
Aug 27, 2013·Early Human Development·Massimo PifferiGiuseppe Saggese
Jul 11, 2012·European Journal of Pediatrics·Mieke BoonKris De Boeck
Feb 24, 2016·Paediatric Respiratory Reviews·Lucy C Morgan, Catherine S Birman
Dec 15, 2015·Revue des maladies respiratoires·I Honoré, P-R Burgel
Sep 30, 2015·Pediatric Pulmonology·Adam J ShapiroUNKNOWN Genetic Disorders of Mucociliary Clearance Consortium
Dec 14, 2011·Current Opinion in Allergy and Clinical Immunology·Raewyn Campbell

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