Primary, combined, atypical carcinoid and squamous cell carcinoma of the larynx: a new variety of composite tumour

The Journal of Laryngology and Otology
C R Davies-HusbandH Hellquist

Abstract

We report the first case of a laryngeal composite tumour consisting of a squamous cell carcinoma combined with an atypical carcinoid. Case report and review of the literature concerning laryngeal composite tumours. Primary laryngeal carcinoma is the most common malignancy of the upper aerodigestive tract. The vast majority are of the squamous cell type. Primary neuroendocrine neoplasms represent a rare, heterogeneous subset of laryngeal malignancies, comprising typical carcinoid, atypical carcinoid, small cell carcinoma and paraganglioma. Primary combined neuroendocrine and squamous cell carcinoma of the larynx is even more rarely encountered, with only 14 publications of this so-called composite tumour to date. In each case, the neuroendocrine component has been small cell carcinoma. The treatment of primary neoplasms comprising more than one histological type is tailored to the most biologically aggressive tumour. Accurate diagnosis of the histological nature of laryngeal composite tumours is imperative to ensure optimal therapy.

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Citations

Jan 1, 2011·Case Reports in Ophthalmological Medicine·Hayato MitamuraShuichi Yamamoto
Jul 1, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Kenneth O DevaneyAlessandra Rinaldo
Jun 2, 2015·Internal Medicine·Mikio OkazakiHironori Izutani
Sep 4, 2015·Nihon Jibiinkoka Gakkai kaiho·Hiroyuki HanakawaKazunori Nishizaki
May 25, 2013·Acta Cirúrgica Brasileira·Maria Aparecida Coelho de Arruda HenryMaria Aparecida Marchesan Rodrigues
Mar 24, 2011·International Journal of Surgical Pathology·Christopher L Owens, Armando E Fraire
Mar 25, 2017·Advances in Anatomic Pathology·Jennifer L HuntAntonio Cardesa

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