PMID: 8952560Dec 15, 1996Paper

Primary combined malignant melanoma and ductal carcinoma of the breast. A report of two cases

Cancer
R F PadmoreA S Patchefsky

Abstract

Tumors consisting of a combination of malignant melanoma and carcinoma are very rare. The authors report two such cases occurring as primary breast tumors. The breast tumors were analyzed by histologic, immunohistochemical, and ultrastructural techniques. Histologically, the tumors were composed of a closely related admixture of ductal adenocarcinoma and malignant melanoma with abundant melanin pigment. Ductal carcinoma in situ was identified in both cases, confirming their origin in the breast. In both tumors, double-labeling immunohistochemistry showed that the epithelial component was immunoreactive for cytokeratin, the melanoma component was immunoreactive for HMB45, and both components were immunoreactive for S-100 protein. Immunostains for estrogen and progesterone receptors were negative in both tumors. Electron microscopy demonstrated glandular lumens and junctional complexes in the epithelial component and melanosomes and premelanosomes in the melanoma component. In one of the cases, rare tumor cells contained both premelanosomes and desmosomes. Combined malignant melanoma and carcinoma is a rare tumor. Only a handful of cases have been reported. The authors report two such cases occurring as primary tumors of the brea...Continue Reading

Citations

Apr 8, 2014·Annales de pathologie·Rim KallelTahya Boudawara
Oct 10, 1998·The British Journal of Dermatology·K SaitohK Maeda
Jun 27, 2006·Journal of Clinical Pathology·Philip C W LuiAye T Khin
Oct 10, 2006·International Seminars in Surgical Oncology : ISSO·Kirstin A CarswellGerald P H Gui
Nov 17, 2007·Journal of Cutaneous Pathology·Mordechai M TarlowRobert A Schwartz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.