Primary conization overcomes the risk of developing local recurrence following laparoscopic radical hysterectomy in early stage cervical cancer.

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Giorgio BoganiFrancesco Raspagliesi

Abstract

To investigate whether primary conization might overcome the risk of local dissemination in patients undergoing laparoscopic radical hysterectomy. Consecutive data of 262 patients with early stage cervical cancer were retrieved: 88 women had conization followed by radical hysterectomy. A propensity-matched comparison (1:1) was carried out in order to compare laparoscopy and open surgery. Accumulating data highlighted that minimally invasive surgery has been associated with higher recurrence rates and worse overall survival than open surgery in women with early stage cervical cancer. Data of 35 paired patients (total 70 patients) were analyzed. No between-group differences in baseline, disease, and pathological variables were observed. Patients undergoing laparoscopy correlated with lower blood loss (50 [range 30-100] vs 150 [range 50-500] mL; P<0.001) and shorter length of stay (3 ± 0.8 vs 5.4 ± 1.4 days; P<0.001) compared to open surgery. One local recurrence was observed per group (P=1.00). Type of surgical approach did not influence site of recurrence (P=1.00) or survival outcomes, in terms of 10-year disease-free (P=0.549, log-rank test) and overall survivals (P=0.615, log-rank test). The data show that primary conization m...Continue Reading

References

Apr 5, 2014·Journal of Minimally Invasive Gynecology·Giorgio BoganiFabio Ghezzi
Sep 23, 2014·The Journal of Sexual Medicine·Giorgio BoganiFabio Ghezzi
Aug 9, 2017·Annals of Surgical Oncology·Denis QuerleuNadeem R Abu-Rustum
Feb 10, 2018·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Valerio GallottaGabriella Ferrandina
Sep 12, 2018·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Jin Hee KimJae Weon Kim
Nov 1, 2018·The New England Journal of Medicine·Alexander MelamedJ Alejandro Rauh-Hain
Nov 1, 2018·The New England Journal of Medicine·Pedro T RamirezAndreas Obermair
Nov 6, 2018·Gynecologic Oncology·Koji MatsuoMikio Mikami
Sep 10, 2019·Critical Reviews in Oncology/hematology·Giorgio BoganiFrancesco Raspagliesi
May 26, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Giorgio BoganiFrancesco Raspagliesi

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Citations

May 26, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Giorgio BoganiFrancesco Raspagliesi

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