Primary Cutaneous B-Cell Lymphomas: An Update

Frontiers in Oncology
Paola VitielloGiuseppe Argenziano

Abstract

Primary cutaneous B-cell lymphomas (PCBCLs) comprise a group of extranodal B-cell non-Hodgkin lymphomas B-cell derived, which primarily involve the skin without evidence of extracutaneous disease at the time of diagnosis. They include ~25% of all cutaneous lymphomas and are classified in three major subgroups (World Health Organization (WHO) 2017): primary cutaneous marginal zone lymphoma (PCMZL), primary cutaneous follicle-center cell lymphoma (PCFCL), and diffuse large B-cell lymphoma, leg type (PCDLBCL, LT). This classification also includes some less common entities such as intravascular large B-cell lymphoma. Recently, WHO-EORTC added Epstein-Barr virus positive (EBV+) mucocutaneous ulcer, as a new provisional distinct entity, to cutaneous B-cell lymphomas. PCBCLs are classically characterized by patches, plaques, or nodules showing great variability for color, shape, and location. Diagnosis requires histological examination with immunohistochemical staining. In general, therapeutic options depend on the exact histological and immunohistochemical classification, disease presentation, and risk assessment. PCMZL and PCFCL are considered indolent lymphomas with a good prognosis and are associated with 5-year disease-specific ...Continue Reading

References

Jun 4, 2004·The Journal of Investigative Dermatology·Christian HallermannChristine Neumann
Oct 6, 2004·British Journal of Haematology·Andrés J M FerreriUNKNOWN International Extranodal Lymphoma Study Group (IELSG)
Feb 5, 2005·Blood·Rein WillemzeChris J L M Meijer
Feb 24, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pier Luigi ZinzaniUNKNOWN Italian Study Group for Cutaneous Lymphomas
Sep 30, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hisashi TakinoHiroshi Inagaki
Nov 21, 2008·The Journal of Investigative Dermatology·Nancy J SenffCornelis P Tensen
Feb 16, 2010·The American Journal of Surgical Pathology·Stefan D DojcinovElaine S Jaffe
Nov 26, 2010·The American Journal of Surgical Pathology·James T EdingerSteven H Swerdlow
May 25, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nicola CoppolaEvangelista Sagnelli
Sep 3, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Nicola CoppolaEvangelista Sagnelli
Jun 26, 2013·Journal of the American Academy of Dermatology·Octavio ServitjeM Teresa Estrach
Sep 17, 2013·The Journal of Investigative Dermatology·Kaveri Korgavkar, Martin A Weinstock
Apr 13, 2015·International Journal of Radiation Oncology, Biology, Physics·Lena SpechtUNKNOWN International Lymphoma Radiation Oncology Group
Oct 5, 2015·Dermatologic Clinics·Lauren C Pinter-Brown
Dec 18, 2016·Seminars in Diagnostic Pathology·Steven H Swerdlow
Apr 13, 2017·Indian Journal of Dermatology·R La SelvaP Quaglino
Aug 29, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·S GellerP L Myskowski
May 3, 2018·Seminars in Cutaneous Medicine and Surgery·Steven T ChenLyn Duncan
Jul 23, 2018·Dermatology : International Journal for Clinical and Investigative Dermatology·Vincenzo PiccoloGiuseppe Argenziano
Nov 1, 2018·Annals of Diagnostic Pathology·Kate E Grimm, Dennis P O'Malley
May 29, 2019·International Journal of Dermatology·Stefano CaccavaleGiuseppe Argenziano
Jun 13, 2019·Hematological Oncology·Werner KempfChristina Mitteldorf
Nov 24, 2019·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Michael OertelHans Theodor Eich
Dec 5, 2019·Frontiers in Oncology·Giulia Tadiotto CicognaMauro Alaibac
Dec 18, 2019·Open Medicine·Antonello SicaBeniamino Casale
Jan 22, 2020·Minerva medica·Antonello SicaElvira Moscarella
Feb 6, 2020·International Journal of Environmental Research and Public Health·Antonello SicaCaterina Sagnelli
Feb 9, 2020·International Journal of Environmental Research and Public Health·Roberto CasconeAlfonso Fiorelli
Mar 25, 2020·Translational Lung Cancer Research·Alfonso FiorelliUNKNOWN LuCiLyS study group
Apr 8, 2020·Open Medicine·Antonello SicaAndrea Ronchi

❮ Previous
Next ❯

Citations

Jun 20, 2020·Journal of Medical Virology·Antonello SicaCaterina Sagnelli
Nov 4, 2020·Intractable & Rare Diseases Research·Nikolaos S SalemisLeonidas Marinos
Dec 8, 2020·Frontiers in Neurology·Antonello SicaAlfonso Papa
Mar 18, 2021·Clinical, Cosmetic and Investigational Dermatology·Andrea RonchiRenato Franco
Jun 10, 2021·Journal of Surgical Case Reports·Shih-Feng Huang, Wen-Chung Liu
Nov 20, 2021·Journal of Cutaneous Pathology·Jack LeeAlejandro A Gru

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.