Abstract
Marginal zone B-cell lymphoma (MZBL) is occasionally associated with prominent plasma cell differentiation. However, MZBL rarely exhibits histological features that resemble plasmacytoma arising from a localized plasma cell variant of Castleman's disease (PCCD). We here report a histologically similar case that was associated with primary cutaneous tumor. The patient was a 57-year-old woman with a 5-year history of cutaneous nodules. Histologically, a prominent proliferation of plasma cells occupied the interfollicular area of the central portion of the cutaneous tumor, whereas various numbers of CD5+ centrocyte-like (CCL) cells, which were arranged in a marginal zone distribution pattern, occupied the peripheral region of the tumor. The majority of the lymphoid follicles had atrophic or regressive germinal centers resembling hyaline-vascular Castleman's disease. CCL cells were observed to have colonized a few of the lymphoid follicles. Immunohistochemistry revealed that these cells had a monotypic intracytoplasmic kappa chain. Without treatment, the patient was quiescent, but 2 years later, there was a transformation to the large cell type. These observations suggest that MZBL needs to be distinguished from PCCD, and that untr...Continue Reading
References
Feb 1, 1979·Cancer·S E JonesC A Coltman
Nov 1, 1992·The American Journal of Surgical Pathology·G G DavisJ B Cousar
Oct 1, 1990·International Journal of Dermatology·R TorneH Kerl
Jan 1, 1989·Histopathology·T RadaszkiewiczK Lennert
May 1, 1994·Histopathology·D T NguyenR Fischer
Aug 1, 1993·Histopathology·J U RijlaarsdamR Willemze
Jan 1, 1996·American Journal of Clinical Pathology·J A FerryN L Harris
Mar 1, 1996·American Journal of Clinical Pathology·D M MenkeR Parwaresch
Jan 23, 1999·American Journal of Clinical Pathology·J W HussongG Frizzera
Dec 16, 2000·The American Journal of Surgical Pathology·J P Duong Van HuyenJ Diebold
Nov 29, 2002·Blood·Emanuele ZuccaUNKNOWN International Extranodal Lymphoma Study Group
Jan 29, 2003·Cancer Genetics and Cytogenetics·Kenichi NomuraMasafumi Taniwaki
Mar 21, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Masaru KojimaNobuhide Masawa
Dec 4, 2004·Cancer·Apostolia-Maria Tsimberidou, Michael J Keating
Feb 5, 2005·Blood·Rein WillemzeChris J L M Meijer
Jun 11, 2005·Human Pathology·Eiichi AraiTakanori Hirose
Sep 21, 2005·Archives of Dermatology·J J HoefnagelR Willemze
Citations
Nov 30, 2012·The American Journal of Dermatopathology·Cynthia M MagroGarth Fraga
Feb 16, 2012·Diagnostic Pathology·Tadashi Terada
Oct 16, 2009·Cases Journal·Takahiro MoriHaruo Ohtani
Mar 22, 2014·Diagnostic Pathology·Noémi EszesVeronika Müller
Mar 13, 2012·Human Pathology·Jesse JasoC Cameron Yin
Oct 15, 2013·American Journal of Clinical Pathology·Jesse Manuel JasoL Jeffrey Medeiros
Jan 11, 2007·American Journal of Clinical Pathology·Adam C SeegmillerNitin J Karandikar
Jun 9, 2020·Journal of Cutaneous Pathology·Robert E LeBlancFrederick Lansigan