Abstract
Primary cutaneous cribriform carcinoma (PCCC) is a rare and under-recognized variant of sweat gland carcinoma, characterized by anastomosing tubules and solid nests producing a sieve-like appearance. Six cases of PCCC were clinically, histopathologically and immunophenotypically studied. All cases showed an unencapsulated, nodular dermal tumor composed of solid and cribriform nests, cords and tubules embedded within a desmoplastic stroma. Some tubules showed micropapillary projections reminiscent of tubular adenoma, and intraluminal thin bridges resembling adenomatoid tumor. One case showed a predominantly solid component. Only two cases showed very focal decapitation secretion. Tumor cells expressed CK7, CK5/6, EMA, CEA, S-100, BerEP4 and c-kit and were negative for cytokeratin 20, estrogen receptor/progesterone receptor (ER/PR), androgen receptor and GCDFP-15. Calponin, p63 and smooth muscle actin (SMA) showed absence of a myoepithelial layer. Contrary to the original reports, our series shows that PCCC may be predominantly solid with only a minor cribriform component, and expresses c-kit and S-100 which may potentially lead to the misdiagnosis of adenoid cystic carcinoma. Immunohistochemical stains may aid in distinction fro...Continue Reading
References
Dec 1, 1991·Acta Pathologica Japonica·A YoshidaH Yoshida
Feb 1, 1986·The American Journal of Dermatopathology·M R Wick, P E Swanson
Jun 1, 1987·The American Journal of Dermatopathology·E Sánchez YusS Coca Menchero
Mar 15, 1994·Cancer·T Y WongM C Mihm
Jan 14, 1998·American Journal of Clinical Pathology·M R WickP E Swanson
Dec 17, 1998·The American Journal of Dermatopathology·N KatoT Onozuka
Apr 3, 1999·Journal of the American Academy of Dermatology·S E ChangJ K Koh
Jul 13, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·C Y Castro, M Deavers
Sep 6, 2001·The Journal of Laryngology and Otology·S S ChuP J Lou
Jul 27, 2002·The American Journal of Dermatopathology·Elena CastelliRosa Maria Tomasino
Oct 23, 2003·Annals of Diagnostic Pathology·Ondrej HesMichal Michal
Dec 19, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M MinoW C Faquin
Jun 25, 2005·Journal of Clinical Pathology·T MiyamotoT Yoshino
Aug 24, 2005·Journal of Cutaneous Pathology·Henri AdamskiJacqueline Chevrant-Breton
May 17, 2006·International Journal of Surgical Pathology·S CrippaA Faravelli
Dec 19, 2007·Medical Molecular Morphology·Angel Fernandez-FloresLuis G Crespo
Mar 19, 2008·The American Journal of Surgical Pathology·Alistair RobsonEduardo Calonje
Oct 31, 2008·The American Journal of Surgical Pathology·Ilan WeinrebDanny M Ghazarian
Sep 16, 2009·Journal of the American Academy of Dermatology·Arno RüttenLuis Requena
Feb 15, 2011·Journal of the American Academy of Dermatology·Dmitry V KazakovMichal Michal
May 17, 2012·The American Journal of Dermatopathology·Denisa KacerovskaDmitry V Kazakov
Sep 13, 2013·The American Journal of Surgical Pathology·Rathi RamakrishnanEduardo Calonje
Citations
Jun 9, 2016·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A UdvardiA Rütten
Oct 21, 2016·Journal of Cutaneous Pathology·Michael D ChangWonwoo Shon
Nov 20, 2016·Journal of Cutaneous Pathology·Carlos N Prieto-GranadaJane L Messina
Mar 4, 2017·The Journal of Dermatology·Shin-Ichi Ansai
Mar 1, 2017·Case Reports in Pathology·Banu Ince AlkanNazan Bozdoğan
Sep 6, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ryan BognerGeorge Gataky
May 10, 2018·The American Journal of Dermatopathology·Masahiro HayashiTamio Suzuki
Sep 29, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Thomas Brenn
Sep 13, 2020·Journal of Cutaneous Pathology·Ingrid FerreiraNicolas de Saint Aubain
Dec 6, 2017·Journal of Cutaneous Pathology·Mar Llamas-VelascoArno Rütten
Dec 20, 2019·The American Journal of Dermatopathology·Christina HopkinsYve Thaller Huttenbach
Jul 25, 2019·The American Journal of Dermatopathology·Masahiro HayashiTamio Suzuki
Dec 3, 2020·Journal of Pathology and Translational Medicine·Hyun LeeChan-Sik Park
Jun 3, 2021·International Journal of Molecular Sciences·Iga PłachtaPiotr Rutkowski
Jul 29, 2020·Annales de pathologie·Sarah MenguyBéatrice Vergier