Primary cutaneous infection with Scedosporium apiospermum successfully treated with voriconazole

Mycoses
K Stur-HofmannK Rappersberger

Abstract

We describe a 61-year-old male patient with a history of long-term corticosteroid treatment for chronic obstructive pulmonary disease, who developed subcutaneous nodules on his right forearm. Histopathologic examination showed large epitheloid cell granulomas with multinuclear giant cells that contained hyphae within their cytoplasm. Microbiological testing of biopsies revealed an infection with Scedosporium apiospermum with resistance to common antifungal agents like fluconazole, itraconazole or amphotericin B and sensitivity to voriconazole. After two months of oral therapy with voriconazole the skin lesions have completely cleared according to clinical and sonographic investigations. Adverse effects like nausea and increased photosensitivity immediately disappeared after finishing the 6-month period of voriconazole treatment.

Citations

Oct 29, 2011·Journal of Cutaneous Pathology·Melody K HarrisonWang L Cheung
Sep 29, 2011·The Journal of Dermatology·Kozo YonedaYasuo Kubota
Mar 24, 2016·Pediatric Dermatology·Princess Curtis, Marcia Hogeling
Sep 18, 2014·The Journal of Dermatology·Ji Seok KimByung Cheol Park

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An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

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An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

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