PMID: 15365364Sep 15, 2004Paper

Primary cutaneous mucinous carcinoma: presence of myoepithelial cells as a clue to the cutaneous origin

The American Journal of Dermatopathology
Hina S QureshiMin W Lee

Abstract

Primary cutaneous mucinous carcinoma (PCMC) is a rare malignancy with probable apocrine differentiation. It is important to differentiate it from metastatic mucinous carcinoma (MMC), especially from the breast. The histologic and immunohistochemical features overlap between PCMC and breast mucinous carcinomas. In this study, we introduce the presence of myoepithelial component in PCMC as a new morphologic parameter to distinguish it from MMC from either breast or sites elsewhere in the body. We studied 7 cases of PCMC. The possible in situ component in the tumor was assessed by the presence of a peripheral myoepithelial cell layer. Myoepithelial cell differentiation was confirmed with immunohistochemical stains for p63, CK 5/6, calponin, smooth muscle actin (SMA), HHF-35, and CD10. Estrogen and progesterone receptor (ER/PR), gross cystic disease fluid protein (GCDFP 15), CK7, CK20, and S-100 immunostains were also performed. Histologically, multiple small monomorphic epithelial islands floating in multilocular pools of mucin characterized the tumor. Focally, epithelial islands were bordered by dermal connective tissue at the periphery of mucin pools. Secretory snouts were apparent in all cases providing evidence for apocrine di...Continue Reading

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Citations

Sep 15, 2004·The American Journal of Dermatopathology·Philip E LeBoit
Sep 23, 2008·The American Journal of Dermatopathology·Sabela ParadelaEduardo Fonseca
Sep 3, 2011·The American Journal of Dermatopathology·Rubeta N MatinRino Cerio
Jul 1, 2011·Indian Dermatology Online Journal·Kavita Mardi, Vijay Kumar Diwana
Oct 19, 2012·Indian Journal of Dermatology, Venereology and Leprology·Ahmed Alhumaidi
Jul 19, 2014·Indian Journal of Dermatology, Venereology and Leprology·Debarshi SahaAshwani Kumar
Feb 7, 2008·Journal of Cutaneous Pathology·Bettina G ZelgerBernhard Zelger
Mar 11, 2015·The Australasian Journal of Dermatology·Hsien ChanDelwyn Dyall-Smith
Oct 1, 2009·Journal of Cutaneous Pathology·Gillian LevyJennifer M McNiff
Oct 17, 2009·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Ina M Scholz, Wolfgang Hartschuh
Feb 25, 2015·International Journal of Surgery Case Reports·Osama S Al BeteddiniRana Shahab
Jan 26, 2018·Journal of Pathology and Translational Medicine·Sun-Ju Oh, Young-Ok Kim
Sep 5, 2018·Journal of Cutaneous Pathology·You-Na SungKyung-Ja Cho
Jan 31, 2006·Journal of Cutaneous Pathology·A Vodovnik
Oct 14, 2017·Journal of Cutaneous Pathology·Valentina Logunova, Olayemi Sokumbi
Nov 21, 2019·International Journal of Molecular Sciences·Artem SmirnovEleonora Candi

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