PMID: 8599480Dec 1, 1995Paper

Primary cutaneous T-cell-rich B-cell lymphoma. A case report with a 13-year follow-up

The American Journal of Dermatopathology
S N DommannG Burg

Abstract

Cutaneous B-cell lymphomas constitute approximately 20% of primary cutaneous lymphomas. Most histologic subtypes of nodal B-cell lymphomas also occur primarily in the skin. The recently described T-cell-rich B-cell lymphomas (TCRBCLs) manifest mainly in the lymph nodes. This article presents a case of TCRBCL arising primarily in the skin, the origin of which could be traced back 13 years. The patient is a 59-year-old man. Plaque-like and nodular skin infiltrates had first appeared in the left preauricular region. Repeated examinations never found any extracutaneous involvement. A skin biopsy and a retrospectively studied 10-year-old skin specimen showed identical histologic features. Immunohistochemistry identified the TCRBCL previously considered as cutaneous Hodgkin's disease or a diffuse centroblastic centrocytic non-Hodgkin's lymphoma. A clonal B-cell population was detected by polymerase chain reaction, showing a rearrangement of IgH gene. The case of this patient shows that primary cutaneous TCRBCLs, similarly to other B-cell lymphomas in the skin, may have a good prognosis, in contrast to their nodal counterparts.

Citations

Jan 31, 1998·The American Journal of Dermatopathology·E J GlusacB R Smoller
Apr 30, 1999·Leukemia & Lymphoma·B BättigM F Fey
Dec 19, 2006·Research in Veterinary Science·C M de BruijnT S G A M van den Ingh
Nov 13, 2015·Anais Brasileiros De Dermatologia·Margarida Lima
May 5, 2011·Dermatology : International Journal for Clinical and Investigative Dermatology·Pamela VezzoliEmilio Berti
Nov 19, 2005·Journal of Cutaneous Pathology·Günter BurgSean Whittaker
Feb 24, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S LiM J Borowitz

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