Primary data, claims data, and linked data in observational research: the case of COPD in Germany

Respiratory Research
Sabrina MuellerThomas Wilke

Abstract

Real-world evidence (RWE) can inform patient management decisions, but RWE studies are associated with limitations. Linkage of different RWE data types could address such limitations by enriching data and improving scientific quality. Using the example of chronic obstructive pulmonary disease (COPD) in Germany, this study assessed the value of data linkage between primary and secondary data sources for RWE. Post hoc analysis of data from an observational RWE study, which used prospectively collected data and data from an insurance claims database to assess treatment adherence and persistence in patients with COPD in Germany. Patient-level primary data were collected from the prospective observational study (primary dataset, N = 636), and claims data from the sickness fund AOK Nordost (claims dataset, N = 74,916). Primary and claims data were linked at a patient level using insurance numbers (linked dataset). Patients in the linked dataset were indexed at date of study inclusion for primary data and matched calendar date for claims data. Agreement between primary and claims data was examined for patients in the linked dataset based on comparisons between recorded sociodemographic data at index, comorbidities (primary: any record...Continue Reading

References

Sep 25, 2007·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Louis P GarrisonC Daniel Mullins
Nov 27, 2007·Clinical Therapeutics·Robert J LigthelmPaul Valensi
Aug 4, 2010·Plastic and Reconstructive Surgery·Christopher J Pannucci, Edwin G Wilkins
Mar 22, 2012·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Marc L BergerSharon-Lise Normand
Dec 15, 2012·Pharmacoepidemiology and Drug Safety·Rachael BoggonMike A Richards
Feb 20, 2014·Health Informatics Journal·Suzanne L WestAnn Larsen
Jun 28, 2014·Biochemia Medica·Matthew S Thiese
Jul 18, 2017·JAMA : the Journal of the American Medical Association·Jonathan P JarowJanet Woodcock

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Citations

Jan 7, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Fränce HardtstockRobert Welte

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