Primary Diffuse B-Cell Thyroid Lymphoma: Case Report and Literature Review

Case Reports in Oncology
Hassan AlyamiEmad Mohammed Al-Osail

Abstract

Primary thyroid lymphoma (PTL) is a rare disease, accounting for 5% of all thyroid malignancies. Diffuse B-cell lymphoma (DBCL) is the most common type of PTL. The diagnosis of PTL depends on biopsy results, and its management depends on the histological type. A 66-year-old female complained of a huge neck mass on the right side that had started growing 3 months previously and was associated with compressive and B symptoms. She had undergone left hemithyroidectomy 20 years previously. On examination, a huge neck mass measuring 10 × 6 cm was detected on the right side that had shifted the trachea to the contralateral side. CT scanning revealed a huge soft tissue mass in the neck with compressive signs. Fine-needle aspiration (FNA) showed variably sized lymphocytes and large epithelial cells with occasional atypical cells. Tissue biopsy revealed DBCL, which is suggestive of PTL. PTL affects only the thyroid gland and the regional lymph nodes. Most PTL originate from B cells, especially DBCL, which accounts for 50-80% of all PTL. FNA may have limited capability to differentiate between anaplastic carcinoma of the thyroid and thyroid lymphoma. If FNA fails to determine PTL tissue, it should be determined using biopsy. A multidiscip...Continue Reading

References

Jan 11, 2001·Clinical Imaging·S TakashimaS Sone
Jul 6, 2004·Current Treatment Options in Oncology·Sandy Widder, Janice L Pasieka
May 26, 2010·Asian Journal of Surgery·Basro Sarinah, Abdullah-Noor Hisham
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Jul 25, 2013·The Oncologist·Siun WalshRuth S Prichard
Oct 21, 2016·International Journal of Surgery·Riaz A AghaUNKNOWN SCARE Group

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Methods Mentioned

BETA
X-ray
biopsy
surgical resection

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