Primary diffuse leptomeningeal gliomatosis in a 2-year-old girl

Surgical Neurology
Lutz DörnerH Maximilian Mehdorn

Abstract

Primary diffuse leptomeningeal gliomatosis is a rare tumor disease affecting the leptomeninx of the CNS. It is thought to originate from subarachnoidal glial cell nests. The symptoms are often rather unspecific. Surgery is not an option and despite the use of chemotherapy and radiotherapy patients rarely survive for more than 12 months. We present a case of PDLG in a 2-year-old girl, the youngest patient reported on so far. She presented with increasing somnolence, intermittent strabism, and vomiting. Magnetic resonance imaging of the cranium showed enlarged ventricles and contrast enhancement of the basal leptomeninx. Cerebrospinal fluid diagnostic studies showed a mild pleocytosis and elevated protein levels but no tumor cells or evidence of infection. A ventriculoperitoneal shunt was placed and a biopsy of the leptomeninx was taken in the right Sylvian fissure. The histopathology findings suggested a nonspecific meningeal inflammation. Because the girl developed spinal symptoms with paresthesia and hyperalgesia, a spinal MRI was performed which showed a similar contrast enhancement of the spinal leptomeninx. A spinal biopsy was taken and subsequently a paucicellular astrocytic tumor was diagnosed corresponding to a WHO I dif...Continue Reading

References

Jan 1, 1990·Acta Neuropathologica·D A RamsayS Nag
Jan 1, 1995·Neurosurgery·L R RogersL Harrold
Jan 1, 1995·Acta neurochirurgica·M T GiordanaA Attanasio
Mar 1, 1993·Journal of Neuro-oncology·P Y DietrichG P Pizzolato
Dec 16, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·J H ReesT Revesz
Feb 13, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·A BaborieJ M Bamford
Aug 1, 1957·Neurology·J KOREINM F SHAPIRO
Jan 1, 1951·Journal of Neuropathology and Experimental Neurology·I S COOPER, J W KERNOHAN

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Citations

Jan 6, 2010·Pediatric Blood & Cancer·Sue ManleyBarry Pizer
Nov 29, 2013·Journal of Child Neurology·Muhammet KoskerYildiz Camcioglu
Sep 24, 2011·Journal of Child Neurology·Jean-Pierre de ChadarévianChristos D Katsetos
Nov 29, 2016·Case Reports in Neurological Medicine·Ehtasham AhmadApostolos Vrettos

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