PMID: 7938760Jan 1, 1994Paper

Primary disseminated form of Ewing sarcoma in association with hypercalcemia and acute renal failure

Renal Failure
L A LozanceG J Zafirovski


We present a case of an extremely rare form of Ewing sarcoma--primary disseminated, with fulminating course, severe hypercalcemia, extensive calcium deposition in parenchymatous organs, including kidneys, and acute renal failure as a clinical consequence. Correction of hypercalcemia was followed by prompt restoration of the glomerular filtration rate (GFR), suggesting that hypercalcemia had a direct effect on its regulation independent of the renal tubular damage. The effectiveness of the treatment with indomethacin indirectly supports the possibility of prostaglandin-mediated humoral hypercalcemia of malignancy.


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Apr 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Alan R SchnedMichael C Chobanian

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