Primary drug resistance to anti-tuberculosis drugs in major towns of Amhara region, Ethiopia

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Solomon Abebe YimerCarol Holm-Hansen

Abstract

Drug resistance is a major obstacle to effective TB control program performance. In this study, we assessed the prevalence of primary drug resistance in Mycobacterium tuberculosis (Mtb) isolates in Amhara Region, Ethiopia. A total of 112 Mtb isolates from cases with newly diagnosed pulmonary TB were subjected to drug susceptibility testing (DST) in a cross-sectional study. Isolates were tested for sensitivity to isoniazid, rifampicin, ethambutol, and streptomycin using the MGIT 960 protocol. A total of 93 Mtb isolates yielded valid DST results and 28 (30.1%) were resistant to one or more of first line anti-TB drugs. One isolate (1.0%) was multi-drug resistant (MDR), five (5.4%) were classified as poly-resistant and 22 showed single drug resistance to either streptomycin (n = 19) or isoniazid (n = 3). Isolates from HIV-positive patients were more likely to be resistant to at least one of the four anti-TB drugs compared with HIV-negative individuals (odds ratio 2.76, 95% confidence interval 1.06-7.22; p = 0.03). The study showed a high prevalence of primary drug resistance. Even though the prevalence of MDR was low, conditions that can contribute to the development of MDR are increasing. Therefore, regular monitoring of drug resi...Continue Reading

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Citations

Feb 17, 2015·Antimicrobial Resistance and Infection Control·Fantahun BiadglegneArne C Rodloff
Dec 5, 2017·Global Health Research and Policy·Yohannes Teka MazeingiaYadeta Dessie
Jun 1, 2018·Journal of Pathogens·Solomon Weldegebreal AsgedomHailay Gebreyesus
Aug 31, 2019·Advances in Preventive Medicine·Alemayehu RetaAbeba Mengist

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