Primary duodenal adenocarcinoma associated with neurofibromatosis type 1

Journal of Gastroenterology
Young-Eun JooSei-Jong Kim

Abstract

It is well known that patients with neurofibromatosis have an increased incidence of various neoplasms, most of these being tumors of neural-crest origin, including neurofibromas, leiomyomas, ganglioneuromas, paragangliomas, and carcinoids. However, the occurrence of small-bowel adenocarcinoma is rare. In this article, we report a patient with small-bowel adenocarcinoma, the seventh such reported case. We include a review of the literature and a brief discussion of the implications of this association. We suggest that the association between small-bowel adenocarcinomas and neurofibromatosis may not be fortuitous, and that small-bowel adenocarcinoma should be considered, in particular. in the differential diagnosis of gastrointestinal symptoms in patients with neurofibromatosis. Also, a definite histologic diagnosis must be made, with the employment of special staining techniques, because of the differing prognoses for various cell types.

Citations

Jan 10, 2008·Diseases of the Colon and Rectum·James J WoodAlan M Roe
Mar 20, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Daniel RellesCharles J Yeo
Jan 14, 2012·The Oncologist·Sachin Patil, Ronald S Chamberlain
Mar 31, 2005·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Angela D LevyLeslie H Sobin
Oct 3, 2008·World Journal of Surgical Oncology·Georgios AnastasopoulosIoannis Vassiliou
May 29, 2009·European Journal of Cancer Care·Charalabos StratopoulosE Hadjiyannakis
Mar 4, 2005·The American Journal of Gastroenterology·Thierry DelaunoitCharles Erlichman

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