Primary empty sella, galactorrhea, hyperprolactinemia and renal tubular acidosis.

The American Journal of Medicine
R S BarW B Malarkey

Abstract

Discussed here is a 41 year old woman with galactorrhea associated with the empty sella syndrome and mild renal tubular acidosis. Basal serum prolactin (PRL) levels were normal, but a 24 hour serum PRL secretory profile demonstrated an increased mean PRL concentration. Serum PRL was appropriately suppressed by the administration of L-dopa; however, chlorpromazine stimulation resulted in a blunted serum PRL response. Pituitary luteinizing hormone, follicle stimulating hormone, ACTH and thyroid stimulating hormone levels were normal. Thus, galactorrhea associated with an enlarged sella does not establish the diagnosis of a pituitary tumor, and pneumoencephalography must be performed to exclude the empty sella syndrome.

Citations

Mar 17, 1977·The New England Journal of Medicine·D L KleinbergA G Frantz
Apr 1, 1981·Postgraduate Medical Journal·B VelkeniersG Copinschi
May 1, 1978·Journal of the American Geriatrics Society·D MehtaP Mathew
May 1, 1983·The American Journal of Medicine·P W StacpooleW R Fisher
Sep 1, 1982·The American Journal of the Medical Sciences·J J Szwed, M Clarke

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