Primary end-point times, functional outcome and adverse event profile after acute ischaemic stroke

International Journal of Stroke : Official Journal of the International Stroke Society
M AliVISTA investigators

Abstract

Poststroke complications such as pulmonary embolism, deep vein thrombosis and pneumonia can impact outcome by causing deterioration in general health, delaying or preventing rehabilitation. While stroke carries a direct risk of complications, some events may be unrelated to index stroke severity and could confound outcome. We examined whether the presence of complications 'unrelated' to index stroke at later time-points could confound outcome, and if this could be minimised through altering study end-points. We analysed 531 placebo-treated patients from the Virtual International Stroke Trials Archive who had experienced an acute ischaemic stroke and at least one poststroke complication during the 90-day follow-up period. We categorised complications into those deemed 'related' or 'unrelated' to index stroke severity. We examined modified Rankin Scale at 30 and 90 days, stratified by type of complication and assessed the impact of eliminating 'unrelated' complications on functional outcome (modified Rankin Scale) at 30 and 90 days using logistic regression (accounting for age and baseline National Institutes of Health Stroke Scale). The majority of complications in the early acute period after index stroke were 'stroke related' ...Continue Reading

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Citations

Jul 10, 2012·Stroke; a Journal of Cerebral Circulation·Dawn KleindorferBrett M Kissela
May 8, 2010·International Journal of Stroke : Official Journal of the International Stroke Society·C WeimarUNKNOWN VISTA Steering Committee
Aug 16, 2012·Cadernos de saúde pública·Tiótrefis G FernandesPaulo A Lotufo
Aug 2, 2014·Stroke; a Journal of Cerebral Circulation·Kerrick HesseUNKNOWN VISTA Collaborators
Jan 9, 2016·Stroke; a Journal of Cerebral Circulation·Kerrick HesseUNKNOWN VISTA Collaborators

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