Primary Epstein-Barr virus infection in immunocompetent patients with acute transverse myelitis and a combination of polyradiculitis and anterior horn syndrome as neurological manifestations

BMJ Case Reports
Michiel H F PoorthuisJelle R de Kruijk

Abstract

Neurological manifestations of a primary Epstein-Barr virus (EBV) infection are rare. We describe a case with acute transverse myelitis and another case with a combination of polyradiculitis and anterior horn syndrome as manifestations of a primary EBV infection.The first case is a 50-year-old immunocompetent male diagnosed with acute transverse myelitis, 2 weeks after he was clinically diagnosed with infectious mononucleosis. The second case is an 18-year-old immunocompetent male diagnosed with a combination of polyradiculitis and anterior horn syndrome while he had infectious mononucleosis. The first patient was treated with methylprednisolone. After 1 year, he was able to stop performing clean intermittent self-catheterisation. The second patient completely recovered within 6 weeks without treatment.Primary EBV infection should be considered in immunocompetent patients presenting with acute transverse myelitis and a combination of polyradiculitis and anterior horn syndrome. Antiviral treatment and steroids are controversial, and the prognosis of neurological sequelae is largely unknown.

References

Nov 21, 1968·The New England Journal of Medicine·A S EvansR W McCollum
May 1, 1969·Journal of Clinical Pathology·V Basson, A A Sharp
May 1, 1994·Pediatric Neurology·K P Connelly, L D DeWitt
Jan 1, 1994·The American Journal of the Medical Sciences·C CaldasJ P Luby
Feb 25, 1998·Journal of Neurovirology·E P CorssmitP Bakker
Apr 20, 1999·Pediatric Neurology·M WongM J Noetzel
Feb 19, 2000·Scandinavian Journal of Infectious Diseases·D Torre, R Tambini
Jun 28, 2000·Current Opinion in Neurology·P Portegies, N Corssmit
Sep 19, 2002·Neurology·UNKNOWN Transverse Myelitis Consortium Working Group
Oct 29, 2002·Annals of Neurology·Adriana WeinbergKenneth L Tyler
Feb 14, 2003·Internal Medicine·Hiroshi FujimotoMasahide Kaji
Sep 23, 2003·Current Opinion in Infectious Diseases·Tom Solomon, Hugh Willison
Feb 8, 2008·Seminars in Neurology·Anu Jacob, Brian G Weinshenker
Nov 13, 2010·Scandinavian Journal of Infectious Diseases·Erik BathoornSteven F T Thijsen
Oct 25, 2011·BMC Infectious Diseases·Timi MarteliusVeli-Jukka Anttila
Nov 30, 2011·Current Opinion in Hematology·Evridiki K VouloumanouMatthew E Falagas
Nov 29, 2012·Neurologic Clinics·Shin C BehElliot M Frohman
Aug 21, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·William G Notcutt
Oct 30, 2015·Journal of Child Neurology·Katarzyna Mazur-MelewskaMagdalena Figlerowicz

❮ Previous
Next ❯

Citations

Apr 26, 2020·Current Opinion in Infectious Diseases·Carlos M Isada, Ryan Miller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.