Primary extramedullary leukemia of the prostate: case report and review of the literature

American Journal of Hematology
E T QuienP Saidi

Abstract

We present the case of a 67-year-old male with primary extramedullary leukemia of the prostate gland, the first reported case in the literature to the best of our knowledge. His initial symptoms consisted of episodes of urinary retention. He underwent transurethral resection of the prostate, and a diagnosis of high-grade lymphoma was rendered. He then received a course of doxorubicin-based lymphoma chemotherapy regimen. However, based on a panel of immunocytochemical stains, a diagnosis of extramedullary leukemia or chloroma was confirmed. His bone-marrow examination at this point was normal. He underwent radiation therapy to the prostate with a total dose of 3960 cGy. Seven months after his initial presentation, he progressed to acute nonlymphocytic leukemia (ANLL), M2 by FAB classification. He was successfully treated with induction and consolidation chemotherapy with Ara-C and idarubicin, and was maintained in complete remission up to 19 months of follow-up. Eight other cases of prostatic leukemia reported in the literature are presented. Five cases occurred in association with ANLL, 2 cases as sites of ANLL relapse, and 1 case in association with myelodysplasia. The use of immunohistochemical stains has aided us in diagnosi...Continue Reading

References

Jun 1, 1990·British Journal of Urology·Y F Chan
Sep 1, 1988·The American Journal of Surgical Pathology·F R DaveyD Y Mason
Dec 15, 1986·Cancer·J M MeisJ T Manning
May 1, 1966·Journal of Clinical Pathology·N B BennettD Ogston
Aug 1, 1983·International Journal of Radiation Oncology, Biology, Physics·L Y ChakR S Cox
Jul 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J C ByrdN A Dawson
Sep 1, 1995·Annals of Internal Medicine·K R ImrieA Keating
Oct 1, 1993·The American Journal of Surgical Pathology·S T TraweekR K Brynes
May 1, 1960·The British Journal of Surgery·J R TIGHE
Oct 1, 1947·The Journal of Urology·E N LUBINL A ERF

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Citations

Jan 1, 2004·The Lancet Oncology·Sebastian SpethmannGert Tuinmann
Sep 24, 1999·Leukemia & Lymphoma·W GorczycaK Seiter
Oct 30, 2003·Critical Reviews in Clinical Laboratory Sciences·A Shabaik
May 22, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Takuo MaruyamaHiroki Shima
Jan 4, 2012·Histopathology·Gladell P PanerMahul B Amin
Mar 11, 1999·American Journal of Hematology·T MatthesS Diebold-Berger
Oct 11, 2005·Pediatric Emergency Care·James A Meltzer, Paul T Jubinsky
Jun 2, 2018·Case Reports in Hematology·Ryan Nguyen, Hamid Sayar
Sep 24, 2020·Abdominal Radiology·Pankaj NepalVijayanadh Ojili

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