Primary extramedullary myeloid tumor of the breast: a case report and review of the literature

Annals of Hematology
A Quintas-CardamaJ Forteza

Abstract

Primary extramedullary myeloid tumors (PEMMT) are extramedullary proliferations of myeloid cells occurring in the absence of an antecedent myeloproliferative disorder. They have predilection for the skin, lymph nodes, central nervous system, and small intestine. Breast is an uncommon location for PEMMT and only a few cases have been reported so far in the medical literature. Many of these cases have been initially misdiagnosed. We reviewed all the reported cases of PEMMT of the breast in the English-language literature since 1965. In addition, we present a new case of PEMMT of the breast who presented with a mass in her right breast mimicking a breast malignancy and was initially misdiagnosed as non-Hodgkin's lymphoma. A careful histologic examination with immunohistochemical studies revealed the presence of PEMMT of the breast. Treatment with systemic chemotherapy and local radiotherapy rendered a complete remission. Seventeen cases of PEMMT of the breast were reported in the English literature from 1965 to 2003. Most of the cases were misdiagnosed initially as lymphomas, breast carcinomas, or malignant melanomas. PEMMT of the breast is a poorly recognized entity whose diagnosis frequently challenges both the pathologist and t...Continue Reading

Citations

Jul 1, 2005·Journal of Cutaneous Medicine and Surgery·Shane G SilverNigel J Ball
Jan 8, 2009·Diagnostic Pathology·Teresa A Vela-ChávezFalko Fend
Oct 7, 2005·International Journal of Hematology·Naohiro SekiguchiKensei Tobinai
Aug 1, 2013·Annals of Hematology·Boting WuShanhua Zou
Jan 7, 2011·Case Reports in Medicine·Ibrahim ElghissassiHassan Errihani
Dec 16, 2006·Leukemia & Lymphoma·Isabel Cunningham
Dec 16, 2006·Leukemia & Lymphoma·Semra PaydasMelek Ergin
Dec 2, 2015·Oncology Letters·Xiao-E HuangXiao-Dong Zhou
Jan 18, 2016·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·S YossiA d'Hombres
Jan 31, 2012·American Journal of Hematology·Isabel Cunningham
Nov 5, 2019·Pediatric Hematology and Oncology·Ting ZhouKevin E Fisher
Apr 13, 2012·Acta Radiologica·Alexey SurovJasmin Abbas
Jan 5, 2005·Archives of Pathology & Laboratory Medicine·Jose R ValbuenaL Jeffrey Medeiros

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.