Abstract
Primary fallopian tube carcinoma (PFTC) is a rare malignancy and only sparse data exist on its possible association with postmenopausal hormone therapy (HT). We therefore studied this association in a nationwide cohort of Finnish HT users. All women> 50 years using systemic estradiol-only therapy (ET) (n=117,820 hysterectomized women) or estradiol-progestin therapy (EPT) (n=247,781 nonhysterectomized women) for ≥ 6 months during 1994-2008 were identified from the national medical reimbursement register. The incidence of PFTC in HT users was compared to that in the comparable background population (standardized incidence ratio, SIR, with 95% confidence interval, CI). A total of 160 cases of PFTC were encountered in users of ET (n=34) or EPT (n=126). The use of EPT ≥ 5 years was accompanied by an increased risk for PFTC (SIR 2.15; 95% CI 1.66-2.72). The SIR increased further to 3.36 (95% CI 2.02-5.24) when EPT use lasted ≥ 10 years. The EPT-related risk for PFTC was restricted to the sequential EPT and it was not seen for continuous EPT. Two leading progestins in EPT, norethisterone acetate and medroxyprogesterone acetate, associated with comparable risk elevations. ET use was not associated with the risk for PFTC. The long-term,...Continue Reading
References
Jan 1, 1989·Acta Oncologica·P PfeifferE Honore
Nov 1, 1989·Gynecologic Oncology·K A RosenblattS M Schwartz
May 1, 1995·Endocrinology·K AdachiY Sakoyama
Jan 1, 1994·Acta Oncologica·L TeppoM Lehtonen
Oct 9, 1999·Maturitas·P TopoA Uutela
Sep 21, 2000·Journal of the National Cancer Institute·K SyrjäkoskiH Nevanlinna
Feb 21, 2003·International Journal of Cancer. Journal International Du Cancer·Annika RiskaEero Pukkala
Jun 13, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A RiskaA Leminen
Sep 5, 2006·The Oncologist·Dimitrios PectasidesTheofanis Economopoulos
Nov 23, 2006·The Journal of Pathology·Y LeeC P Crum
Dec 2, 2006·Obstetrics and Gynecology·Heli LyytinenOlavi Ylikorkala
Jan 16, 2007·Current Opinion in Obstetrics & Gynecology·Christopher P CrumYonghee Lee
Feb 21, 2007·BJOG : an International Journal of Obstetrics and Gynaecology·A RiskaA Leminen
Feb 23, 2007·Cancer·James V LaceyLouise A Brinton
May 29, 2008·International Journal of Cancer. Journal International Du Cancer·Dieter Flesch-JanysJenny Chang-Claude
Nov 26, 2009·Obstetrics and Gynecology·Susanna JaakkolaOlavi Ylikorkala
Mar 17, 2010·International Journal of Cancer. Journal International Du Cancer·Kjersti BakkenFranco Berrino
May 11, 2010·Gynecologic Oncology·Danielle VicusUNKNOWN Hereditary Ovarian Cancer Clinical Study Group
Sep 3, 2010·JAMA : the Journal of the American Medical Association·Susan M DomchekTimothy R Rebbeck
May 30, 2012·Climacteric : the Journal of the International Menopause Society·V Koskela-NiskaO Ylikorkala
Citations
Mar 26, 2013·International Journal of Cancer. Journal International Du Cancer·Virpi Koskela-NiskaTadeusz Dyba
Apr 8, 2015·International Journal of Cancer. Journal International Du Cancer·Virpi Koskela-NiskaTadeusz Dyba
Sep 24, 2016·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Abigail WhealLynn Hirschowitz
Feb 27, 2020·Diagnostics·Isao Otsuka, Takuto Matsuura
May 1, 2021·International Journal of Molecular Sciences·Isao Otsuka