Primary fecal diversion and bowel dysfunction in restorative proctocolectomy for ulcerative colitis: a nationwide cross-sectional study

International Journal of Colorectal Disease
Anders Mark-ChristensenSøren Laurberg

Abstract

The aim of this study was to explore the effects of primary fecal diversion on the risk of pouch dysfunction. Patients operated with an ileal pouch-anal anastomosis in Denmark in 2000-2010 were identified and validated bowel function questionnaires retrieved from a cross-sectional study. Multivariate logistic regression analysis was performed to determine the effect of primary fecal diversion on pouch dysfunction. A diagnostic or procedural code for intraabdominal abscesses and fistulas, occurring within 1 year after pouch creation, and anastomotic leakage or extremely early-onset pouchitis within 30 days of surgery defined a pelvic complication. The questionnaire response rate was 85.6% (504 of 589), with no relevant differences in clinical characteristics between responders and non-responders. Pelvic complications, pouch failure, and death prior to the questionnaire date were more common for patients without primary fecal diversion. Among patients without primary fecal diversion, the prevalence of pouch dysfunction was 48% (95% CI: 34-62%), compared to 30% (95% CI: 26-35%) for those with [adjusted odds ratio = 2.23 (95% CI: 1.20-4.14)]. This difference was primarily caused by a higher risk of 'urgency', 'incomplete emptying',...Continue Reading

References

Sep 1, 1992·The British Journal of Surgery·S P GroblerM R Keighley
Oct 1, 1990·Diseases of the Colon and Rectum·W E Roediger
Jan 1, 1996·The British Journal of Surgery·O Hallböök, R Sjödahl
Aug 2, 2003·Annals of Surgery·Hagit TulchinskyJohn Nicholls
Oct 8, 2003·Annals of Surgery·Victor W FazioConor P Delaney
Mar 7, 2006·Diseases of the Colon and Rectum·Feza H RemziIan C Lavery
Jan 17, 2007·The British Journal of Surgery·D HahnloserR R Dozois
Jan 19, 2007·Gut·Leith WilliamsDermot Burke
Apr 23, 2008·Archives of Surgery·Gina K Weston-PetridesParis P Tekkis
Feb 6, 2010·Annals of Surgery·Ravi P KiranVictor W Fazio
Mar 20, 2012·Diseases of the Colon and Rectum·James M KielyRavi P Kiran
May 8, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S BrandsborgS Laurberg
Oct 5, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Coen L KlosSekhar Dharmarajan
Oct 10, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S BrandsborgS Laurberg
Jun 27, 2014·European Journal of Epidemiology·Morten SchmidtHenrik Toft Sørensen
Nov 26, 2015·Clinical Epidemiology·Morten SchmidtHenrik Toft Sørensen
Feb 9, 2016·Diseases of the Colon and Rectum·Anders Mark-ChristensenAnders Tøttrup
Jul 2, 2017·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A Mark-ChristensenS Laurberg

❮ Previous
Next ❯

Citations

Dec 13, 2018·Diseases of the Colon and Rectum·Philip H SossenheimerDavid T Rubin
Apr 1, 2021·Revista do Colégio Brasileiro de Cirurgiões·Adriana Cherem-AlvesRodrigo Gomes DA-Silva
Jun 8, 2021·Digestive Diseases and Sciences·Chiara RocchiDario Sorrentino

❮ Previous
Next ❯

Related Concepts

Related Feeds

22q11 Deletion Syndrome

22q11.2 deletion syndrome, also known as DiGeorge syndrome, is a congenital disorder caused by a partial deletion of chromosome 22. Symptoms include heart defects, poor immune system function, a cleft palate, complications related to low levels of calcium in the blood, and delayed development. Discover the latest research on this disease here.