Primary gastric mantle cell lymphoma in a patient with long standing history of Crohn's disease

Leukemia & Lymphoma
Markus RadererAndreas Chott

Abstract

The stomach is the most common site of primary extranodal lymphoma. Virtually all cases are of B-cell lineage, including extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT lymphoma) and diffuse large B-cell lymphomas. While secondary gastric involvement from nodal mantle cell lymphoma (MCL) or in the course of primary intestinal MCL (lymphomatous polyposis) have been described, primary gastric MCL has not been reported so far. A 74-year-old man with a 14 year-history of Crohn's disease was admitted at a general hospital due to epigastric pain refractory to therapy with proton-pump inhibitors. Endoscopy disclosed a large polypoid tumor with an ulcerated surface at the greater curvature of the gastric antrum. Endosonography demonstrated the tumor to be limited to the stomach with only local lymph node involvement. Histology of gastric biopsies revealed a dense atypical lymphoid infiltrate composed of small to medium sized cells with slightly irregular nuclear contours. Immunohistochemichally, the cells were positive for CD20, CD79a, CD43 and cyclin D1, but negative for CD3, CD5 and bcl-6. They stained for IgM and showed lambda-light chain restriction. Fluorescent in situ hybridisation studies sho...Continue Reading

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Citations

Dec 24, 2011·Gut and Liver·Chang Ha KimInsun Kim
Oct 16, 2014·Journal of Gastrointestinal Cancer·Lokanatha DasappaK C Lakshmaiah
Mar 29, 2007·Journal of the Chinese Medical Association : JCMA·Ying-Ying YangShou-Dong Lee
Dec 1, 2006·Expert Review of Anticancer Therapy·Brendan C DicksonRunjan Chetty
May 3, 2019·The American Journal of Surgical Pathology·Yuan MiaoShaoying Li
Feb 20, 2008·Pathology, Research and Practice·Yosep ChongKwang Hwa Park
Sep 15, 2010·Annales de pathologie·Mériam Bel Haj SalahSamia Chatti-Dey

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