Primary gastrointestinal follicular lymphoma: a clinicopathologic study of 13 cases from Taiwan

Journal of Clinical Gastroenterology
Wan-Ting HuangShih-Sung Chuang

Abstract

Follicular lymphoma (FL) is a common nodal lymphoma. Primary gastrointestinal follicular lymphoma (GIFL) is rare and most commonly occurs in the elder women with indolent clinical course, mainly in the duodenum and terminal ileum. We conducted this study to characterize GIFL in Taiwan. A total of 13 cases were retrospectively collected in 4 hospitals in southern and eastern Taiwan up to 2006. Pathology review and immunohistochemistry were performed and the clinical data were obtained from chart review. There were 5 men and 8 women with a median age of 58 years (range, 31 to 74; mean, 55). The most frequent site was ileum (7/13, 54%) with 4 tumors in the terminal ileum and the most common symptom was abdominal pain (8/13, 62%). Multiple lymphomatous polyposis was present in 6 patients (46%). Five (45%) of 11 tumors with surgical resection showed transmural involvement. Most of the cases revealed a predominantly follicular pattern (7/13, 54%) and low-grade disease (grades 1 and 2; 10/13, 77%). The tumors expressed CD10 (62%), Bcl-2 (77%), Bcl-6 (77%), and MUM1 (38%). Five patients (38%) were at stage IE and 8 (62%) at stage IIE. Treatment included surgery with or without chemotherapy. All patients achieved complete remission and ...Continue Reading

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Citations

Jun 30, 2009·The American Journal of Surgical Pathology·Shih-Sung ChuangHongxiang Liu
Jan 19, 2010·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Taiji AkamatsuEiji Tanaka
Jan 20, 2010·Journal of Gastroenterology·Shuji YamamotoTsutomu Chiba
Jun 27, 2009·Leukemia & Lymphoma·Sheau-Fang YangShih-Sung Chuang
Mar 9, 2010·Best Practice & Research. Clinical Gastroenterology·Markus Raderer, Jan Paul de Boer
Dec 18, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Amy L LightnerMarcia M Russell
Jun 10, 2016·Journal of Gastrointestinal Cancer·Brian T MoyHaleh Vaziri
Jun 6, 2012·The American Journal of Gastroenterology·Johanna IturrinoTodd H Baron
Apr 16, 2013·Internal Medicine·Masaya IwamuroHiroyuki Okada
Jul 3, 2018·Oncology Letters·Hee Young NaJi Eun Kim
Dec 16, 2020·BMJ Case Reports·Hwei Jene NgPatrick Collins

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