PMID: 8615089Jan 1, 1995Paper

Primary germinoma of the spinal cord: a case report with 28-year follow-up and review of the literature

Acta Neuropathologica
D D SlagelS A Moore

Abstract

Germ cell neoplasms occur in extra-gonadal midline locations of the retroperitoneum, mediastinum, pineal gland, areas of the suprasellar cistern, and rarely in the spinal cord. We recently reviewed a case of an unresectable lumbar spinal cord tumor in a 16-year-old female previously diagnosed as "metastatic poorly differentiated carcinoma." An extensive evaluation for a primary neoplasm at that time was unsuccessful and the patient was treated with local radiation therapy. Recently, additional histochemical and immunocytochemical studies were performed on the archival formalin-fixed paraffin-embedded material and the clinical history was reviewed. These ancillary studies (including positive immunohistochemical staining for placental alkaline phosphatase) support a diagnosis of intramedullary germinoma of the conus medullaris. This patient has enjoyed 28 years of disease free survival which reflects the radiosensitive nature of this neoplasm. These data lend support to the existence of a primary germinoma in the spinal cord and illustrate the utility of using histochemical stains and immunohistochemistry to assist in diagnosing this treatable neoplasm.

References

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Citations

Nov 4, 2010·Brain Tumor Pathology·Carter S RaboToshiki Yoshimine
Mar 26, 2009·Neurologia Medico-chirurgica·Toru YamagataKenji Ohata
Jul 31, 2010·Neurologia Medico-chirurgica·Yusuke KinoshitaTakashi Watanabe
Jul 21, 2006·Journal of Neurosurgery. Spine·Maura MassiminoFelice Giangaspero
Feb 26, 2009·Acta neurochirurgica·Ahitagni BiswasGoura Kishor Rath
Aug 21, 2013·The Spine Journal : Official Journal of the North American Spine Society·Junkoh YamamotoShigeru Nishizawa
Dec 14, 2011·World Neurosurgery·Vivek A MehtaGeorge I Jallo
May 24, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Alan L MorrisonElisabeth J Rushing
Nov 15, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Ka-Yen YangWu-Fu Chen
Jan 27, 2007·Surgical Neurology·Takeshi AoyamaYoshinobu Iwasaki
Sep 19, 2008·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Nan-Han LuChing-Hui Yeh
Aug 25, 2016·World Neurosurgery·Marina NikitovićMilan Sarić
Dec 3, 2004·Neurosurgery·Jason H HuangLeslie N Sutton
May 24, 2003·Medical and Pediatric Oncology·Argon AndacOnat Haluk
Feb 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L HorvathM Boyer
Jun 15, 2006·Journal of Neuro-oncology·Peter KanRandy L Jensen
Sep 1, 2005·Journal of Neuro-oncology·Ismail H Tekkök, Aydin Sav

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