Primary gliosarcoma of the brain: radiologic and histopathologic features

The Neuroradiology Journal
Alfredo E Romero-RojasAlfonso Lozano-Castillo

Abstract

Gliosarcoma is a rare central nervous system (CNS) neoplasm with biphasic glial and non-glial malignant components. Here we describe the radiologic and histopathologic features observed in five cases of primary gliosarcoma. The mean age at diagnosis in the studied patients was 54.2 years; these patients were predominantly males (male:female ratio = 4:1). At diagnosis all patients had several clinical deterioration. The most common symptoms of presentation were: headache (5/5 cases), seizures (4/5 cases) and hemiparesis (1/5 cases). All the tumors were large (mean major diameter= 4.12±1.64 cm) at diagnosis as evidenced in computer tomography (CT) scans and magnetic resonance images (MRIs), with preferential involvement of the temporal lobe and frequent associated deviation of the midline structures. Other common characteristics identified on CT scans and MRIs were partial contrast medium uptake with annular pattern (5/5 cases), peripheral edema (5/5 cases), and central calcification (3/5 cases). In additional a peak of dye uptake was observed (4/5 cases) on MRI spectrometry. In the histopathology, the glial component showed malignant astrocytes, with high Ki67 (>60%) and p53 positivity; the sarcomatous components displayed pleom...Continue Reading

References

Feb 10, 2000·The American Journal of Pathology·R M ReisH Ohgaki
Oct 2, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J LutterbachA Pagenstecher
Apr 30, 2004·Human Pathology·Eric BehlingLawrence C Kenyon
Aug 31, 2004·Arquivos de neuro-psiquiatria·Tiago Noguchi MachucaLuiz Fernando Bleggi Torres
Aug 2, 2006·Archives of Pathology & Laboratory Medicine·Valeria BarresiGiovanni Tuccari
Dec 16, 2006·Journal of Neuro-oncology·Thomas L BeaumontAndrew E Sloan
Feb 27, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Jens SchittenhelmMichel Mittelbronn
Feb 28, 2007·The American Journal of Surgical Pathology·Fausto J RodriguezJoseph Landolfi
May 23, 2007·Archives of Pathology & Laboratory Medicine·C Ryan Miller, Arie Perry
Jul 21, 2007·Acta Neuropathologica·Mohanpal S DulaiNorman L Lehman
May 15, 2008·Pathology International·Takeaki FukudaToshimitsu Suzuki
Dec 17, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael D PradosDaphne A Haas-Kogan
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Apr 9, 2009·Clinical Nuclear Medicine·Linh Thuy HoJohn Seto
Sep 3, 2010·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Sung Kyoung MoonJuhie Lee
Oct 1, 2011·Clinical Neuropathology·B F M RomeikeI Petersen
Nov 16, 2011·Journal of Computer Assisted Tomography·Bi-Yun ZhangXiao-Qiang Wang
Jul 17, 2012·Clinical Neurology and Neurosurgery·Richa DawarNikhil I Khushalani
May 3, 2013·Head and Neck Pathology·Alfredo E Romero-RojasSandra I Chinchilla-Olaya

❮ Previous
Next ❯

Citations

Jun 24, 2017·The Neuroradiology Journal·Luísa SampaioJosé Fonseca
Oct 9, 2018·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Miriam E PeckhamKaren L Salzman
Nov 21, 2014·Journal of Veterinary Internal Medicine·A FaddaA Oevermann
Jan 6, 2017·Case Reports in Radiology·Quoc-Bao D NguyenJamie J Van Gompel
Oct 23, 2019·JFMS Open Reports·Patricia ÁlvarezMartí Pumarola
Feb 6, 2020·Arquivos de neuro-psiquiatria·Aya FukudaFabiano Reis
Nov 8, 2020·Clinical Neurology and Neurosurgery·Daniela PierscianekRamazan Jabbarli
May 1, 2021·The Neuroradiology Journal·Christoph J MaurerRoland Roelz
May 20, 2021·Radiology Case Reports·Renato Masson de Almeida PradoGustavo Dalul Gomez

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Arquivos de neuro-psiquiatria
Tiago Noguchi MachucaLuiz Fernando Bleggi Torres
Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology
José PardoArnaldo Alvarado
Archives of Pathology & Laboratory Medicine
J J Sreenan, R A Prayson
© 2021 Meta ULC. All rights reserved